NCT04684706Active, not recruiting
Compressed Intermittent Theta Burst Stimulation
A Within Study on the Effects of L-dlPFC Activation Through iTBS in Refractory Depression
Source: ClinicalTrials.gov · Last updated 16 Jan 2026
Brief summary (registry, in English)
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy of intermittent theta-burst stimulation (iTBS) on left dorsolateral prefrontal cortex (L-dlPFC) in a treatment refractory population.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 12 Oct 2020
- Start date
- 20 Feb 2020
- Primary completion date
- 30 Nov 2026
- Lead sponsor
- University of Pennsylvania
- Diseases
- Depression
- NCT number
- NCT04684706
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 20 Feb 2020 to the primary completion date, 30 Nov 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Medical condition that interferes with the collection or interpretation of MRI data
- Implanted devices such as: aneurysm clip or cardiac pacemaker
- Diagnosis of stroke, epilepsy, or other neurological disorders interfering with treatment at PI discretion
- Current alcohol or substance use disorder in last 3 months
Other
- Pregnancy (Female participants)
- MRI contraindication
- Any factor the investigator believe may affect participant safety or compliance (ex: ≥100 miles from clinic)
Who the study is looking for
- Gender, inclusive
- 18 - 70 years of age
- Meets Diagnostic and Statistical Manual of Mental Disorders criteria for primary diagnosis of MDD
- Patients must be fluent in English
- Participants must have the ability to provide consent
- Montgomery Asberg Depression Rating Scale score ≥20
- Failed 2+ prior treatments (treatment-refractory)
- May be on current anti-depressant medication at the discretion of PI, if not exceeding doses that would make TMS an increased risk
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Interventional Psychiatry, University of California San Diego Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Center for Neuromodulation in Depression and Stress Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.