NCT04685135Active, not recruitingPhase 3
Phase 3 Study of MRTX849 vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
A Randomized Phase 3 Study of MRTX849 versus Docetaxel in Patients with Previously Treated Non-Small Cell Lung Cancer with KRAS G12C Mutation
Source: EU CTIS (euclinicaltrials.eu) · Last updated 2 Nov 2026
Brief summary (registry, in English)
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 557 (estimated)
- First submitted
- 5 Jun 2024
- Start date
- 23 Dec 2020
- Lead sponsor
- Mirati Therapeutics Inc.
- Diseases
- Lung cancer
- NCT number
- NCT04685135
- EU CT number
- 2023-507263-19-00
- EudraCT number
- 2020-003645-11
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 557
- 111 sites in 14 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, sotorasib).
Other illness
- Crossover Exclusion Criteria: Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.
Other
- Active brain metastases
Who the study is looking for
- Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
- Candidacy to receive treatment with docetaxel.
- Crossover Inclusion Criteria: Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
- Crossover Inclusion Criteria: ECOG performance status 0 - 2.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (111)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Landeskrankenanstalten-Betriebsgesellschaft Kabeg Coordinator of this site? Confirm its status | Klagenfurt Am Woerthersee | Austria | Completed |
| Grand Hopital de Charleroi Coordinator of this site? Confirm its status | Charleroi | Belgium | Active, not recruiting |
| Antwerp University Hospital Coordinator of this site? Confirm its status | Edegem | Belgium | Active, not recruiting |
| Az Maria Middelares Gent Coordinator of this site? Confirm its status | Gent | Belgium | Active, not recruiting |
| JESSA Ziekenhuis Coordinator of this site? Confirm its status | Hasselt | Belgium | Active, not recruiting |
| UZ Brussel Coordinator of this site? Confirm its status | Jette | Belgium | Active, not recruiting |
| Algemeen Ziekenhuis Delta Coordinator of this site? Confirm its status | Roeselare | Belgium | Active, not recruiting |
| Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur Coordinator of this site? Confirm its status | Yvoir | Belgium | Active, not recruiting |
| University Hospital Olomouc Coordinator of this site? Confirm its status | Olomouc | Czechia | Completed |
| Zentralklinik Bad Berka GmbH Coordinator of this site? Confirm its status | Bad Berka | Germany | Active, not recruiting |
| Universitaetsklinikum Giessen und Marburg GmbH Coordinator of this site? Confirm its status | Giessen | Germany | Active, not recruiting |
| SLK-Kliniken Heilbronn GmbH Coordinator of this site? Confirm its status | Loewenstein | Germany | Active, not recruiting |
| Muenchen Klinik gGmbH Coordinator of this site? Confirm its status | Munich | Germany | Active, not recruiting |
| Complexo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Active, not recruiting |
| Hospital General Universitario Dr. Balmis Coordinator of this site? Confirm its status | Alicante | Spain | Active, not recruiting |
| Institut Catala d'Oncologia Coordinator of this site? Confirm its status | Badalona | Spain | Active, not recruiting |
| Hospital Universitario de Cruces Coordinator of this site? Confirm its status | Barakaldo | Spain | Active, not recruiting |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Universitari Dexeus Grupo Quironsalud Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Institut Català d'Oncologia Coordinator of this site? Confirm its status | Girona | Spain | Active, not recruiting |
| Hospital Universitario Virgen de las Nieves Coordinator of this site? Confirm its status | Granada | Spain | Active, not recruiting |
| Complejo Hospitalario Universitario Insular Materno Infantil Coordinator of this site? Confirm its status | Las Palmas de Gran Canaria | Spain | Active, not recruiting |
| Hospital Universitario De Leon Coordinator of this site? Confirm its status | León | Spain | Active, not recruiting |
| Hospital Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Beata María Ana Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Fundación Jiménez Díaz Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Clinica Universidad de Navarra Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Active, not recruiting |
| Hospital Universitario Regional de Málaga Coordinator of this site? Confirm its status | Málaga | Spain | Active, not recruiting |
| University Hospital Son Espases Coordinator of this site? Confirm its status | Palma | Spain | Active, not recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Active, not recruiting |
| Hospital Universitario Marqués de Valdecilla Coordinator of this site? Confirm its status | Santander | Spain | Active, not recruiting |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| Hospital Universitario Y Politecnico La Fe Coordinator of this site? Confirm its status | Valencia | Spain | Active, not recruiting |
| Hospital Clinico Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Active, not recruiting |
| Centre Hospitalier Régional et Universitaire de Brest Coordinator of this site? Confirm its status | Brest | France | Active, not recruiting |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Bron | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Caen Normandie Coordinator of this site? Confirm its status | Caen | France | Active, not recruiting |
| Centre Francois Baclesse Coordinator of this site? Confirm its status | Caen Cedex 5 | France | Active, not recruiting |
| Centre Hospitalier Intercommunal Créteil Coordinator of this site? Confirm its status | Créteil | France | Active, not recruiting |
| Centr Georges Francois Leclerc Coordinator of this site? Confirm its status | Dijon | France | Active, not recruiting |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | Grenoble Cedex 9 | France | Active, not recruiting |
| Hopital Cardiologique Coordinator of this site? Confirm its status | Lille Cedex | France | Active, not recruiting |
| Centre Hospitalier Et Universitaire De Limoges Coordinator of this site? Confirm its status | Limoges Cedex 1 | France | Active, not recruiting |
| Hospices Civils De Lyon Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Active, not recruiting |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Montpellier Coordinator of this site? Confirm its status | Montpellier Cedex 5 | France | Active, not recruiting |
| Groupe Hospitalier de la Région de Mulhouse et Sud Alsace Coordinator of this site? Confirm its status | Mulhouse | France | Active, not recruiting |
| Centre Antoine Lacassagne Coordinator of this site? Confirm its status | Nice Cedex 2 | France | Active, not recruiting |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Active, not recruiting |
| Centre Hospitalier Intercommunal De Cornouaille Coordinator of this site? Confirm its status | Quimper Cedex | France | Active, not recruiting |
| Institut De Cancerologie De L Ouest Coordinator of this site? Confirm its status | Saint-Herblain Cedex | France | Active, not recruiting |
| Centre Regional Lutte Contre Le Cancer Coordinator of this site? Confirm its status | Strasbourg | France | Active, not recruiting |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex | France | Active, not recruiting |
| Centre Hospitalier Regional Universitaire De Tours Coordinator of this site? Confirm its status | Tours Cedex 9 | France | Active, not recruiting |
| Les Hopitaux Nord-Ouest Coordinator of this site? Confirm its status | Villefranche Sur Saone Cedex | France | Active, not recruiting |
| Institut Gustave Roussy Coordinator of this site? Confirm its status | Villejuif | France | Active, not recruiting |
| Thoracic General Hospital of Athens "I Sotiria" Coordinator of this site? Confirm its status | Athens | Greece | Active, not recruiting |
| Henry Dunant Hospital Center Coordinator of this site? Confirm its status | Athens | Greece | Active, not recruiting |
| General Oncological Hospital Of Kifissia Agioi Anargyroi Coordinator of this site? Confirm its status | Kifissia | Greece | Active, not recruiting |
| General University Hospital of Larissa Coordinator of this site? Confirm its status | Larissa | Greece | Active, not recruiting |
| Metropolitan Hospital Coordinator of this site? Confirm its status | Pireas | Greece | Active, not recruiting |
| Geniko Nosokomeio Thessalonikis George Papanikolaou Coordinator of this site? Confirm its status | Thessaloniki | Greece | Active, not recruiting |
| Athens Medical Center S.A. Coordinator of this site? Confirm its status | Thessaloniki | Greece | Active, not recruiting |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Completed |
| Tallaght University Hospital Coordinator of this site? Confirm its status | Dublin 24 | Ireland | Completed |
| St James's Hospital Coordinator of this site? Confirm its status | Dublin 8 | Ireland | Completed |
| Beaumont Hospital Coordinator of this site? Confirm its status | Dublin 9 | Ireland | Completed |
| University Hospital Limerick Coordinator of this site? Confirm its status | Limerick | Ireland | Completed |
| AORN San Giuseppe Moscati Avellino Coordinator of this site? Confirm its status | Avellino | Italy | Active, not recruiting |
| Istituto Tumori Bari Giovanni Paolo II Coordinator of this site? Confirm its status | Bari | Italy | Active, not recruiting |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Coordinator of this site? Confirm its status | Brescia | Italy | Active, not recruiting |
| Istituto di Candiolo Fondazione del Piemonte per l'oncologia IRCCS Coordinator of this site? Confirm its status | Candiolo | Italy | Active, not recruiting |
| ARNAS Garibaldi Di Catania Coordinator of this site? Confirm its status | Catania | Italy | Active, not recruiting |
| Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania Coordinator of this site? Confirm its status | Catania | Italy | Active, not recruiting |
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genoa | Italy | Active, not recruiting |
| I.R.C.C.S-Azienda Ospedaliera Metropolitana Ospedale Villa Scassi Coordinator of this site? Confirm its status | Genova | Italy | Active, not recruiting |
| Ospedale Vito Fazzi Lecce Coordinator of this site? Confirm its status | Lecce | Italy | Active, not recruiting |
| Istituto Europeo di Oncologia s.r.l Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Azienda Ospedaliero Universitaria Maggiore della Carità Coordinator of this site? Confirm its status | Novara | Italy | Active, not recruiting |
| Hospital Santa Maria Della Misericordia Coordinator of this site? Confirm its status | Perugia | Italy | Active, not recruiting |
| Azienda Sanitaria Territoriale di Pesaro e Urbino Coordinator of this site? Confirm its status | Pesaro | Italy | Active, not recruiting |
| I.F.O. Istituti Fisioterapici Ospitalieri Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Amphia Hospital Coordinator of this site? Confirm its status | Breda | Netherlands | Active, not recruiting |
| Academisch Ziekenhuis Maastricht Coordinator of this site? Confirm its status | Maastricht | Netherlands | Active, not recruiting |
| Radboud Universitair Medisch Centrum (Radboudumc) Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Active, not recruiting |
| St Antonius Ziekenhuis Coordinator of this site? Confirm its status | Utrecht | Netherlands | Active, not recruiting |
| Ms Pneumed Janusz Milanowski Katarzyna Szmygin-Milanowska sp.j. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Specjalistyczna Praktyka Lekarska Slawomir Mandziuk Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy Coordinator of this site? Confirm its status | Otwock | Poland | Active, not recruiting |
| Mruk-Med I Sp. z o.o. Coordinator of this site? Confirm its status | Rzeszów | Poland | Active, not recruiting |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Unidade Local de Saúde de Coimbra, E.P.E. Coordinator of this site? Confirm its status | Coimbra | Portugal | Active, not recruiting |
| Instituto Portugues De Oncologia De Coimbra Francisco Gentil E.P.E. Coordinator of this site? Confirm its status | Coimbra | Portugal | Active, not recruiting |
| Instituto Portugues de Oncologia de Lisboa Francisco Gentil, E.P.E. Coordinator of this site? Confirm its status | Lisbon | Portugal | Active, not recruiting |
| Hospital Cuf Descobertas S.A. Coordinator of this site? Confirm its status | Lisbon | Portugal | Active, not recruiting |
| Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Active, not recruiting |
| Spitalul Judetean de Urgenta "Dr. Constantin Opris" Baia Mare Coordinator of this site? Confirm its status | Baia Mare | Romania | Completed |
| Hyperclinica MedLife Policlinica de Diagnostic Rapid Turnului Brasov Coordinator of this site? Confirm its status | Brasov | Romania | Completed |
| Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti Coordinator of this site? Confirm its status | Bucharest | Romania | Completed |
| Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Completed |
| Medisprof S.R.L. Coordinator of this site? Confirm its status | Cluj-Napoca | Romania | Completed |
| Centrul De Oncologie SF Nectarie S.R.L. Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Oncolab S.R.L. Coordinator of this site? Confirm its status | Craiova | Romania | Completed |
| Centrul De Oncologie-Euroclinic S.R.L. Coordinator of this site? Confirm its status | Iasi | Romania | Completed |
| Ovidius Clinical Hospital S.R.L Coordinator of this site? Confirm its status | Ovidiu | Romania | Completed |
| Oncomed S.R.L. Coordinator of this site? Confirm its status | Timisoara | Romania | Completed |
| Oncocenter Oncologie Clinica S.R.L Coordinator of this site? Confirm its status | Timișoara | Romania | Completed |
Related publications
- Plain language summary of the KRYSTAL-12 study results: adagrasib for non-small cell lung cancer with KRASG12C mutations.Future Oncol · 2026 · PMID 42745627
This page is information, not medical advice. Discuss any trial with your doctor.