NCT04688905Active, not recruiting
Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
Diagnosestellung Der Herzinsuffizienz Mit Erhaltener Ejektionsfraktion Bei Patienten Mit Unklarer Belastungsdyspnoe - Validierung Gegen Den Invasiven Goldstandard (Diagnose-HFpEF)
Source: ClinicalTrials.gov · Last updated 19 Nov 2025
Brief summary (registry, in English)
Invasive diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea NYHA II-III compared to other diagnostic tools
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 30 (actual)
- First submitted
- 4 Dec 2020
- Start date
- 9 Sept 2020
- Primary completion date
- 4 Aug 2023
- Lead sponsor
- University of Leipzig
- Diseases
- Heart failure
- NCT number
- NCT04688905
What you commit to
- Study type: Observational
- Participants enrolled: 30
- From 9 Sept 2020 to the primary completion date, 4 Aug 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- unstable cardiac disease with acute decompensation
- heart valve disease with medium or high grade insufficiency or stenosis
- coronary heart disease with hemodynamically relevant coronary stenosis
- acute or chronic cardiac inflammation (myocarditis, pericarditis)
- former heart transplantation
- relevant pulmonary disease (e.g. COPD) assumably causing the dyspnea
Lab values
- documented former LVEF ≤ 40%
- hemoglobin \< 5 mmol/l
Other
- specific cardiomyopathia
- FEV1/VC \< 70%
- pregnant or nursing women
- contraindication for one of the diagnostic tests
Who the study is looking for
- dyspnea NYHA II-III
- age 18-90 years
- left ventricular ejection fraction ≥ 50%
- ability to give informed consent
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitatsklinikum Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
Related publications
- Diagnosing HFpEF in Patients With Unexplained Dyspnea by Using Invasive Left Ventricular Pressure-Volume Loops.J Card Fail · 2025 · PMID 41233022
This page is information, not medical advice. Discuss any trial with your doctor.