NCT04690322WithdrawnPhase 4
POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies
Source: ClinicalTrials.gov · Last updated 7 Apr 2026
Brief summary (registry, in English)
This is a prospective, randomized control trial in which each patient will be randomly assigned to receive either extended half-life factor VIII based replacement therapy or non-FVIII based replacement therapy, which are both standard of care treatment for persons with Hemophilia A.
- Status (registry)
- Withdrawn
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 27 Dec 2020
- Start date
- 15 Apr 2021
- Primary completion date
- Jul 2027
- Lead sponsor
- University of Texas Southwestern Medical Center
- Diseases
- Haemophilia
- NCT number
- NCT04690322
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Subjects with documented FVIII inhibitor
- Currently using medications known to impact bone and mineral metabolism (e.g., bisphosphonates, corticosteroids, estrogen, testosterone, calcitonin, thyroid hormone therapy);
Other illness
- Subjects with a history of ≥ 2 target joints
- Subjects with a history of synovectomy
- Disease states known to affect bone integrity (e.g., primary hyperparathyroidism, Paget's disease, clinically significant liver disease)
Who the study is looking for
- Subjects with moderate hemophilia A (baseline factor VIII activity 1-5%) or severe hemophilia A (baseline factor VIII activity <1%) on prophylactic standard half-life FVIII infusions OR subjects with moderate or severe hemophilia A who have not started prophylactic treatment
- Less than 18 years of age
Age in the registry: - to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Texas Southwestern Medical Center | Dallas | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.