NCT04699786Active, not recruiting
Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies
Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies: Quantitative Analyses of a Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 10 Mar 2026
Brief summary (registry, in English)
This is a study to evaluate the impact of returning research results that indicate a five-year risk estimate of Alzheimer disease dementia to participants without memory or thinking problems of the Knight Alzheimer Disease Research Center at Washington University in St. Louis.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 450 (estimated)
- First submitted
- 4 Jan 2021
- Start date
- 19 Feb 2021
- Primary completion date
- 10 Jun 2025
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Alzheimer disease
- NCT number
- NCT04699786
What you commit to
- Study type: Interventional
- Planned participants: 450
- From 19 Feb 2021 to the primary completion date, 10 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- There are no exclusion criteria, other than not meeting all of the inclusion criteria listed above.
Who the study is looking for
- Current Knight ADRC participants who had their clinical assessment in the previous year.
- Minimum age of 65 years old
- Participant must be classified as cognitively normal (CDR® = 0) at their last clinical assessment.
- Participant has either recent research brain MRI and amyloid PET scan results, or recent plasma amyloid measurements (ideally within the past two years, but up to five years will be acceptable due to COVID-19-related delays).
- Participant has genetic research results available including APOE status.
- Participant is currently consented to be contacted for other research opportunities through the Knight ADRC.
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
Related publications
- No cognitive or psychological impact from returning research Alzheimer disease biomarkers: A delayed-start, noninferiority, randomized clinical trial.medRxiv · 2026 · PMID 42326827
- What is the psychological and cognitive impact of returning Alzheimer disease dementia research results to healthy research participants? a delayed-start randomised clinical trial protocol for the WeSHARE study (Washington University study of having Alzheimer disease research results explained).BMJ Open · 2026 · PMID 41500647
This page is information, not medical advice. Discuss any trial with your doctor.