NCT04700800Completed
Regulation of Muscle Protein Phenotype in Humans With Obesity
Source: ClinicalTrials.gov · Last updated 5 Nov 2025
Brief summary (registry, in English)
A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes. This alteration can be linked to changes in the expression of myosin heavy chain (MHC) protein isoforms in the skeletal muscle of individuals with obesity. The investigators aim to modulate the metabolism of muscle MHC isoforms to uncover the biological mechanisms underlying this disrupted expression pattern in muscle of humans with obesity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 48 (actual)
- First submitted
- 21 Dec 2020
- Start date
- 7 Oct 2021
- Primary completion date
- 2 Oct 2024
- Lead sponsor
- Mayo Clinic
- Diseases
- Obesity
- NCT number
- NCT04700800
What you commit to
- Study type: Interventional
- Participants enrolled: 48
- From 7 Oct 2021 to the primary completion date, 2 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prescription or over-the-counter medication
- use of anabolic steroids or corticosteroids (within 3 months)
- gastro-intestinal surgery
Other illness
- diabetes
- acute illness
- liver disease
- uncontrolled metabolic disease, including renal disease
- heart disease related to atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure or ECG documented abnormalities
- any other condition or event considered exclusionary by the PI and the study physician.
Lab values
- low hemoglobin or hematocrit
Other
- supplements known to affect protein metabolism (i.e., amino acids, protein, omega-3 fatty acids)
- not classified as inactive/sedentary based on the Stanford Brief Activity Survey and accelerometry data
- participation in a weight-loss regimen
- extreme dietary practices (i.e., vegan, vegetarian)
- smoking
- pregnancy
Who the study is looking for
- ability to sign informed consent form
- body mass index (BMI), 18-26 kg/m2 (lean subjects), 32-50 kg/m2 (subjects with obesity)
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.