NCT04701671Active, not recruiting
Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids
Executive Functioning, Weight Trajectories, and Loss of Control Eating in Children With Overweight/Obesity: A Prospective Study
Source: ClinicalTrials.gov · Last updated 4 Jun 2026
Brief summary (registry, in English)
Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and psychosocial health complications. Although our recently published data suggest that youth with these conditions may have relative deficits in neurocognitive functioning, particularly working memory, understanding of how these processes and their neural correlates are related to change and stability in eating and weight-related outcomes over time is limited, thereby impeding development of targeted, optimally timed interventions. The present study aims to assess prospective associations between general and food-specific executive functioning and underlying neural substrates, and eating and weight outcomes among children at varying levels of risk overweight/obesity and eating disorders, which will help guide research efforts towards the development of effective prevention and intervention strategies.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 180 (estimated)
- First submitted
- 6 Jan 2021
- Start date
- 10 Dec 2020
- Primary completion date
- 9 May 2028
- Lead sponsor
- University of Pittsburgh
- Diseases
- Obesity
- NCT number
- NCT04701671
What you commit to
- Study type: Observational
- Planned participants: 180
- From 10 Dec 2020 to the primary completion date, 9 May 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Not currently taking any medications known to affect weight or appetite
- Free of any current or past medical or psychiatric conditions known to significantly affect eating or weight (e.g., diabetes, bulimia nervosa), with the exception of binge eating disorder
- In the low average range or higher on measures of general intellectual functioning
- Free of any conditions affecting executive functioning (e.g., recent concussion, history of traumatic brain injury)
- Fluent in English, and able to read and comprehend study materials
- Not currently pregnant
Age in the registry: 9 years to 12 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Weight Control & Diabetes Research Center Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.