NCT04707365Not yet recruiting
Microenvironment and Immunity of Digestive Cancers - East Paris Multicentric Cohort
Interactions Between Tumor, Tumor Microenvironment and Immune System in Digestive Cancers : Impact on Survival and Response to Treatment
Source: ClinicalTrials.gov · Last updated 13 Jan 2021 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Colorectal and pancreatobiliary cancers are the most common digestive cancers. Their incidence has particularly increased over the last few decades, leading to suspicion that environmental factors are involved. In addition, strategies for the therapeutic management of these cancers are evolving in the context of the development of immunotherapies. Tumor microenvironment is a potential source of new diagnostic, prognostic and predictive markers and new therapeutic targets. The links between tumor microenvironment and modulation of the immune system in colorectal and pancreatobiliary cancers are poorly understood. Molecular classifications have been proposed for these cancers, but their link with immunity and response to treatment remains to be explored. Objective : explore links between molecular subtypes, tumor microenvironment, host (immune system, pre-metastatic niche, intestinal microbiota, metabolism), and survival (prognostic value), response (predictive value) and tolerance (toxicities) to treatments in digestive cancers, in particular colorectal and pancreatobiliary cancers. Method: Retrospective and prospective monocentric cohort study
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 12 Jan 2021
- Start date
- Mar 2021
- Primary completion date
- Mar 2035
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Pancreatic cancer, Colorectal cancer
- NCT number
- NCT04707365
What you commit to
- Study type: Interventional
- Planned participants: 200
- From Mar 2021 to the primary completion date, Mar 2035
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Persons under psychiatric care
Other
- Patient under guardianship, curatorship or safeguarding of justice
- Pregnant or breastfeeding woman
- Any medical, psychological or social situation that could prevent compliance with the protocol according to the investigator's assessment.
- Refusal to participate in the study
- Patient on AME (state medical assistance)
- Persons deprived of liberty by a judicial or administrative decision
Who the study is looking for
- Colorectal or pancreatic adenocarcinoma or biliary tract adenocarcinoma
- Cytologically or histologically proven adenocarcinoma, regardless of stage and treatment
- Age ≥ 18 years old
- Diagnosed from 2015 onwards
- Signed Consent
- Affiliation to a social security scheme (including CMU (Universal health coverage))
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.