NCT04722835Recruiting
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
Source: ClinicalTrials.gov · Last updated 4 Jun 2026
Brief summary (registry, in English)
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design suitable preventative and therapeutic strategies for its management. This Department of Defense (DOD) discovery research proposes to develop methodologies and generate preliminary data needed to lay the foundation for a large study that would investigate the underlying biological susceptibility of those who smoke tobacco to develop COPD.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 9 Dec 2020
- Start date
- 1 Mar 2021
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- University of California, San Francisco
- Diseases
- COPD
- NCT number
- NCT04722835
What you commit to
- Study type: Observational
- Planned participants: 40
- From 1 Mar 2021 to the primary completion date, 31 Dec 2030
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any history of IV drug use or inhalation of recreational drugs other than marijuana: A- within the past 20 years. B- more than 100 times IV drug usage. C- longer than 1 year usage.
- Serious and active heart conditions- defined by stable or unstable angina, recent myocardial infarction (within the last 2 years), active congestive heart failure, ischemic cardiomyopathy.
- History of chronic active Hepatitis B or C.
Other
- Marijuana use \>400 joints in lifetime or any within past 6 months.
- Inability to walk briskly, run on treadmill, or pedal on ergometer to perform the study-required exercise level.
- Pregnant/breast feeding.
- Liver cirrhosis.
Who the study is looking for
- Ages between 40 to 75 years old.
- History of at least 20 pack-years of smoking.
- No diagnosis of COPD or asthma.
- No spirometric evidence of airflow obstruction as determined by FEV1/FVC ratio ≥0.7.
- FEV1 and FVC \>lower limit of normal.
- Less than 1 pack-year history of tobacco smoking and no tobacco use within the past 12 months.
- Subjects will be divided into two groups by their RV/TLC:
- Normal RV/TLC Group:
- Plethysmographic RV/TLC equal or less than lower limit of normal.
- Abnormal RV/TLC Group:
- Plethysmographic RV/TLC higher than lower limit of normal.
Age in the registry: 40 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Active, not recruiting |
| Zuckerberg San Francisco General Hospital and Trauma Center Coordinator of this site? Confirm its status | San Francisco | United States | Active, not recruiting |
| San Francisco VA Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.