NCT04732910Recruiting
Modulate-CF: Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators
CFTR Biomarker Studie Bei Patient*Innen Mit Mukoviszidose Und CFTR-Modulatortherapie
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
This observational study evaluates the effect of therapy with cystic fibrosis transmembrane regulator (CFTR) modulators on CFTR function measured by the CFTR biomarker intestinal current measurement (ICM), nasal potential difference (NPD) and sweat chloride in a post-approval setting in patients with cystic fibrosis (CF).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 25 Jan 2021
- Start date
- 1 Jul 2018
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Charite University, Berlin, Germany
- Diseases
- Cystic fibrosis
- NCT number
- NCT04732910
What you commit to
- Study type: Observational
- Planned participants: 500
- From 1 Jul 2018 to the primary completion date, 31 Mar 2027
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing participation in an investigational drug study (including studies investigating lumacaftor, tezacaftor or ivacaftor)
Who the study is looking for
- Decision for cystic fibrosis (CF) transmembrane regulator (CFTR)-modulator therapy by the patient and the caring CF physician
- Signed informed consent form (ICF) and, where appropriate, signed assent form.
Age in the registry: 6 months to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Charité Universitätsmedizin Berlin Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Justus Liebig University Giessen Coordinator of this site? Confirm its status | Giessen | Germany | Recruiting |
| Hannover Medical School Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| University of Heidelberg Coordinator of this site? Confirm its status | Heidelberg | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.