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NCT04753970RecruitingPhase 1/2

Retina is a Marker for Cerebrovascular Heath

Retinal Vasoreactivity is a Marker for Cerebral Small Vessel Disease Progression

Source: ClinicalTrials.gov · Last updated 3 Aug 2026

Brief summary (registry, in English)

Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression. This study aims to test whether impaired cerebral and retinal vasoreactivity may serve as biomarker for SVD progression, and to evaluate the safety and efficacy of cilostazol (antiplatelet agent with vasodilatory and anti-inflammatory properties) for the treatment of SVD.

Status (registry)
Recruiting
Phase (registry)
Phase 1/2
Study type
Interventional
Enrollment
100 (estimated)
First submitted
9 Feb 2021
Start date
9 Feb 2021
Primary completion date
Jun 2030
Lead sponsor
Mayo Clinic
NCT number
NCT04753970

What you commit to

  • Study type: Interventional · Phase 1/2
  • Planned participants: 100
  • From 9 Feb 2021 to the primary completion date, Jun 2030
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Age

  • Age\<18yo

Other

  • Pregnant
  • Breast feeding
  • Unable to follow commands
  • Unable to tolerate MRI

Who the study is looking for

  • Age ≥18 yo.
  • Diagnosis of CADASIL, sporadic WMD or lobar CMB and age-matched healthy controls (eg. patient's spouse or unrelated friends without SVD)

Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Mayo Clinic Florida
Coordinator of this site? Confirm its status
JacksonvilleUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.