NCT04757610CompletedPhase 3
A clinical study of OPT-302 with ranibizumab compared to ranibizumab alone in patients with neovascular age-related macular degeneration
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Ranibizumab, Compared with Ranibizumab Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 23 Apr 2025
Brief summary (registry, in English)
To determine the efficacy of intravitreal 2.0 mg OPT-302 when administered in combination with intravitreal 0.5 mg ranibizumab, in participants with neovascular AMD.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 298 (actual)
- First submitted
- 2 Aug 2024
- Start date
- 23 Sept 2021
- Lead sponsor
- Opthea Limited
- Diseases
- Macular degeneration
- NCT number
- NCT04757610
- EU CT number
- 2024-512879-13-00
- EudraCT number
- 2020-004736-24
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 298
- 39 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Study Eye: 1. • Any previous treatment for neovascular AMD.
Other illness
- • Clinically significant ocular disorders (other than neovascular AMD), which may, in the investigator's opinion, interfere with assessment of BCVA, assessment of safety, or fundus imaging.
Who the study is looking for
- • Male or female participants at least 50 years of age.
- • Active subfoveal CNV lesion or juxtafoveal CNV lesion with foveal involvement that is secondary to AMD in the Study Eye.
- • An ETDRS BCVA score between 60 and 25 (inclusive) letters in the Study Eye.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (39)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oftex s.r.o. Coordinator of this site? Confirm its status | Pardubice V | Czechia | Completed |
| Klinika JL MR s.r.o. Coordinator of this site? Confirm its status | Prague | Czechia | Completed |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Completed |
| Medical Private Care s.r.o. Coordinator of this site? Confirm its status | Sokolov | Czechia | Completed |
| Universitaetsmedizin Goettingen Coordinator of this site? Confirm its status | Goettingen | Germany | Completed |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Completed |
| Universitaetsklinikum Muenster AöR Coordinator of this site? Confirm its status | Muenster | Germany | Completed |
| Universitaetsklinikum Ulm AoR Coordinator of this site? Confirm its status | Ulm | Germany | Completed |
| Aarhus Universitetshospital Coordinator of this site? Confirm its status | Aarhus N | Denmark | Completed |
| Rigshospitalet Coordinator of this site? Confirm its status | Glostrup | Denmark | Completed |
| Centro De Oftalmologia Barraquer S.A. Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Universitario De Burgos Coordinator of this site? Confirm its status | Burgos | Spain | Completed |
| Oftalmologia Vistahermosa S.L. Coordinator of this site? Confirm its status | Burjassot | Spain | Completed |
| Clinica De Oftalmologia De Cordoba S.L. Coordinator of this site? Confirm its status | Cordoba | Spain | Completed |
| Instituto De Microcirugia Ocular Dos S.L. Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitari General de Catalunya Coordinator of this site? Confirm its status | Sant Cugat del Vallès | Spain | Completed |
| Hospital Arnau de Vilanova de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Completed |
| Pole Vision Val d'Ouest Coordinator of this site? Confirm its status | Écully | France | Completed |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Completed |
| General Hospital of Athens "G. Gennimatas" Coordinator of this site? Confirm its status | Athens | Greece | Completed |
| University General Hospital of Ioannina Coordinator of this site? Confirm its status | Ioannina | Greece | Completed |
| General University Hospital Of Patras Coordinator of this site? Confirm its status | Patras | Greece | Completed |
| Budapest Retina Associates Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Completed |
| Borsod-Abauj-Zemplen Varmegyei Koezponti Korhaz Es Egyetemi Oktatokorhaz Coordinator of this site? Confirm its status | Miskolc | Hungary | Completed |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Completed |
| Azienda Ospedaliero Universitaria Renato Dulbecco Coordinator of this site? Confirm its status | Catanzaro | Italy | Completed |
| Azienda Sanitaria Locale 2 Lanciano Vasto Chieti Coordinator of this site? Confirm its status | Chieti | Italy | Completed |
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genoa | Italy | Completed |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Azienda Ospedaliera Universitaria Senese Coordinator of this site? Confirm its status | Siena | Italy | Completed |
| Azienda Sanitaria Universitaria Friuli Centrale Coordinator of this site? Confirm its status | Udine | Italy | Completed |
| Pauls Stradins Clinical University Hospital Coordinator of this site? Confirm its status | Riga | Latvia | Completed |
| Centrum Medyczne Dietla 19 Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Centrum Diagnostyki i Mikrochirurgii Oka-Lens Sp. z o.o. Coordinator of this site? Confirm its status | Olsztyn | Poland | Completed |
| Uniwersytecki Szpital Kliniczny Nr 2 PUM w Szczecinie Coordinator of this site? Confirm its status | Szczecin | Poland | Completed |
| Caminomed Sp. z o.o. Coordinator of this site? Confirm its status | Tarnowskie Góry | Poland | Completed |
| Eb Group Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu Coordinator of this site? Confirm its status | Wroclaw | Poland | Completed |
Related publications
- Neovascular age-related macular degeneration management - Beyond anti-VEGF.Indian J Ophthalmol · 2026 · PMID 42054085
This page is information, not medical advice. Discuss any trial with your doctor.