NCT04763317Recruiting
Precision Medicine in the Prostate Cancer Care Pathway
Precision Medicine in the Prostate Cancer Care Pathway: an Evaluation of Integrating Germline Genetic Testing Into the Management of Men at Risk of / Living With Prostate Cancer
Source: ClinicalTrials.gov · Last updated 16 Dec 2025
Brief summary (registry, in English)
This study aims to evaluate the use of a prostate cancer specific predisposition genetic panel test in men with / at high risk of prostate cancer. The genetic test will analyse men's DNA samples for the presence of mutations in rare genes as well as common genetic variation to provide men with information about their risk of prostate cancer. This study will evaluate the clinical impact of the test on risk assessment and clinical management in terms of screening and treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 3000 (estimated)
- First submitted
- 28 Sept 2020
- Start date
- 14 Feb 2019
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- Institute of Cancer Research, United Kingdom
- Diseases
- Prostate cancer
- NCT number
- NCT04763317
What you commit to
- Study type: Observational
- Planned participants: 3000
- From 14 Feb 2019 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- • WHO performance status 4
Who the study is looking for
- Affected cohort:
- Affected with PrCa \< 60 years or
- Affected with metastatic castration resistant PrCa (mCRPC) at any age or Aggressive PrCa Gleason 4+4 or higher \<70 years
- Affected with family history defined as three or more cases any age (FDR or SDR)
- Unaffected cohort: (This cohort is no longer recruiting, it has completed recruitment)
- Aged \>30 and with a family history defined as:
- FDR diagnosed \< 70
- 2 or more cases in First or Second Degree Relatives (FDR/SDR) with one case diagnosed \< 70 years
- 3 or more cases at any age (on same side of family)
Age in the registry: 30 years to 70 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Royal Marsden Hosital, Coordinator of this site? Confirm its status | Sutton | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.