NCT04769310Completed
Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 5 (actual)
- First submitted
- 19 Feb 2021
- Start date
- 26 Apr 2021
- Primary completion date
- 27 Jan 2026
- Lead sponsor
- Tulane University
- Diseases
- Stroke, Atrial fibrillation
- NCT number
- NCT04769310
What you commit to
- Study type: Interventional
- Participants enrolled: 5
- From 26 Apr 2021 to the primary completion date, 27 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any health-related gadolinium/MRI contraindication (including previous allergic reaction to Gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
Other illness
- History of atrial fibrillation
- Patients who had a clinically symptomatic acute stroke within the last 30-days
- Cognitive impairment preventing the patient from giving an informed consent
Lab values
- Estimated glomerular filtration rate (eGFR) cutoff in patients with Chronic kidney disease (CKD) where gadolinium cannot be used equals an eGFR \<30 ml/min
Other
- Weighing \> 300 lbs (as CMR image quality decreases due to increased body mass index)
- Current pregnancy or breastfeeding
Who the study is looking for
- Male or female patients
- 18 Years and older
- No history of atrial fibrillation
- CHA2DS2VASC score ≥3
- History pf type II diabetes
- History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease
Age in the registry: 18 years to 120 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tulane University Medical Center Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.