NCT04774523Completed
Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac Resynchronization
Source: ClinicalTrials.gov · Last updated 18 Sept 2025
Brief summary (registry, in English)
BIO\|Adapt study is designed to provide evidence for the clinical benefit of the CRT AutoAdapt feature. This feature provides continuous adaptation of AV delay and biventricular pacing modality. However, additional clinical data on the short and mid-term improvement of CRT-D patients by the CRT AutoAdapt feature are needed.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 198 (actual)
- First submitted
- 19 Feb 2021
- Start date
- 31 Aug 2021
- Primary completion date
- 31 Jul 2024
- Lead sponsor
- Biotronik SE & Co. KG
- Diseases
- Heart failure
- NCT number
- NCT04774523
What you commit to
- Study type: Interventional
- Participants enrolled: 198
- From 31 Aug 2021 to the primary completion date, 31 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Planned implantation or previous implantation with a BIOTRONIK DX ICD lead
Other illness
- History of persistent/permanent AF
- History of complete AV-block
Who the study is looking for
- Indication for de novo implantation or upgrade to a CRT-D device
- Enrolled in BIO\|STREAM.HF but not yet implanted with or upgraded to CRT-D
- LVEF \< 35%
- QRS \> 120 ms
- NYHA II-IV
- Atrial heart rate during sinus rhythm at rest below 100 bpm
- Patient is able to understand the nature of the study and willing to provide written informed consent to this submodule
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dr Francisco Javier Garcia Coordinator of this site? Confirm its status | Burgos | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.