NCT04782869Completed
Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy
Personalized Multichannel Transcranial Direct Current Electrical Stimulation (tDCS) in Drug-resistant Epilepsy: Evaluation of Therapeutic and Neurophysiological Effects
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
This project aims to conduct a pilot study based on the targeting of the epileptogenic zone previously localized very precisely by stereoelectroencephalography (SEEG). SEEG is used as part of the pre-surgical assessment. It consists, thanks to the intracerebral implantation of electrodes in the brain of patients, to perform an intracerebral electrophysiological recording and thus to precisely explore the epileptogenic regions. In order to study the neuromodulatory and therapeutic effects of tDCS on epileptic brains, non-invasive techniques for measuring electrophysiological brain activity such as magnetoencephalography (MEG) and high-resolution electroencephalography (HR EEG) will be used. Finally, since epilepsy is considered to be a disorder of brain functional networks associated with disturbed brain connectivity, the effects of tDCS on cortical excitability by studying the variations in functional connectivity induced by stimulation will be studied.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 17 (actual)
- First submitted
- 26 Feb 2021
- Start date
- 15 Mar 2021
- Primary completion date
- 20 Feb 2023
- Lead sponsor
- Assistance Publique Hopitaux De Marseille
- Diseases
- Epilepsy
- NCT number
- NCT04782869
What you commit to
- Study type: Interventional
- Participants enrolled: 17
- From 15 Mar 2021 to the primary completion date, 20 Feb 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgeries opening the skull leaving skull defects capable of allowing the insertion of a cylinder with a radius greater or equal to 5 mm.
- Metal inside the head (outside the mouth) such as shrapnel, surgical clips
- Patient currently participating in another clinical trial or having participated in a clinical trial in the month prior to inclusion.
Other illness
- \- Generalized epilepsy
- Skin conditions (e.g., eczema, lesion)
- Any cranial metal implants (excluding \<1 mm thick epicranial titanium skull plates and dental fillings) or medical devices (i.e. cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant).
- Any condition that makes the study subject, in the opinion of the investigator, unsuitable for the study.
Other
- Presenting contraindication to MRI, a serious intercurrent pathology, a progressive brain tumor
- Person protected by articles L1121-5, L1121-6 and L1121-8 of Public Health Code (pregnant or breastfeeding woman, deprived of liberty by judicial decision, situations of social fragility, adults unable or unable to express their consent).
Who the study is looking for
- \- Age: Older than 12 years old
- Patients with drug-resistant focal epilepsy with no surgical indication or with a previous surgical failure or refusing surgery.
- SEEG previously performed before inclusion with an adequate definition of the epileptogenic zone
- A clinical or research MRI scan that is suitable for navigated brain stimulation (NBS) and definition of target area.
- Number of seizures \>3/month during the baseline (before the first session of tDCS treatment), for at least 3 months
- Have stable medications for the whole study duration and few weeks before
- Total IQ\>65
- Be able to understand, speak and write in French
- Patient, parents or legally representative who have given written informed consent to allow the study data collection procedures,
- Be a beneficiary of affiliated to a health insurance plan
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service d'Epileptologie et de Rythmologie Cérébrale Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.