NCT04791371Recruiting
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- First submitted
- 8 Mar 2021
- Start date
- 17 Jun 2022
- Primary completion date
- 15 Jan 2027
- Lead sponsor
- University of Colorado, Denver
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT04791371
What you commit to
- Study type: Interventional
- Planned participants: 150
- From 17 Jun 2022 to the primary completion date, 15 Jan 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnant, nursing or hormonal therapy (other than contraceptives)
Other illness
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
- Obstructive pulmonary disease or asthma
- Physical impairment that would limit exercise ability
- Type 1 diabetes
- Hepatic or renal disease.
Lab values
- Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Control HbA1c \> 5.7, T2DM HbA1c \> 9
Other
- Peripheral neuropathy
- Current or past smoking within the last 1 years
- Current tobacco use
- Anemia
- Peri or post-menopausal women
Who the study is looking for
- Sedentary (defined as less than 1 hour per week of physical activity)
- BMI: 25-40
- Men and women with and without type 2 diabetes
Age in the registry: 30 years to 55 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
Related publications
- Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus.Cardiovasc Diabetol · 2025 · PMID 41361416
This page is information, not medical advice. Discuss any trial with your doctor.