NCT04793750Completed
Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)
Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC): Performance Evaluation of Novel POC HIV Tests in Baltimore
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
This study proposes to investigate the performance of existing and new technologies for HIV diagnosis, one of the key strategies for Ending the HIV Epidemic in the U.S. Current, Standard-of-Care (SOC) diagnostic techniques have extended turn-around-times (TATs) that result in loss of patients to follow up due to delays in laboratory procedures. In this scenario, patients that are at a high-risk for HIV have the potential to continue transmission, making it difficult to end the epidemic. Rapid, Point-of-Care (POC) HIV viral load (VL) testing alleviates this problem by reducing TATs that allow providers to test for HIV infection and link patients to antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) during the same clinical visit, and subsequently, suppress VL, prevent HIV infection, and reduce its transmission among high-risk populations. The study proposes that evaluating the performance of new and existing POC technologies is needed to provide updated information to HIV test providers operating in different populations and settings and improve linkage to HIV treatment and prevention services. The study hypothesizes that: A. Determining the performance characteristics of HIV POC tests will inform optimal testing strategies in different populations and settings B. The use of HIV RNA POC tests will improve linkage to HIV treatment and prevention services: i. Improve early diagnosis of HIV ii. Reduce the time to ART initiation iii. Facilitate timely and appropriate referral for prevention services
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 224 (actual)
- First submitted
- 8 Mar 2021
- Start date
- 18 Aug 2021
- Primary completion date
- 28 Feb 2025
- Lead sponsor
- Johns Hopkins University
- Diseases
- HIV
- NCT number
- NCT04793750
What you commit to
- Study type: Interventional
- Participants enrolled: 224
- From 18 Aug 2021 to the primary completion date, 28 Feb 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Aged \<18 years
Other
- Unwilling to undergo study procedures
- Any other reason deemed pertinent by the study team
Who the study is looking for
- Aged 18 years or older
- Living with or at high risk for HIV (MSM/transgender; injection drug use (IDU); known STI or being screened for STI; part of a high STI prevalence network \[e.g., in the Sexual Health clinic\])
- Willing to undergo phlebotomy and collection of oral fluid samples
- Willing to complete a questionnaire
- Willing to have laboratory results shared with the clinician(s) associated with their care
- Willing to attend follow-up visits
- Willing for samples to be transferred to the CDC for analysis and storage
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The John G. Bartlett Specialty Practice (JGBSP) Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Johns Hopkins Hospital Emergency Department (JHHED) Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| The Baltimore City Health Department (BCHD) Health and Wellness Center, Sexual Health Clinics Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
Related publications
- Next-Day HIV Viral Load Test Result and Linkage to Care Among Persons Living With or at Risk of HIV: A Randomized Clinical Trial.JAMA Netw Open · 2025 · PMID 41400951
This page is information, not medical advice. Discuss any trial with your doctor.