NCT04798924Active, not recruiting
Visual Rehabilitation After Occipital Stroke
Source: ClinicalTrials.gov · Last updated 3 Dec 2025
Brief summary (registry, in English)
This research aims to examine changes in plastic potential of the visual system with time from stroke affecting primary visual cortex. We will measure structural and mechanistic aspects of progressive degeneration along the early visual pathways, correlating them with changes in visual performance, and in responsiveness to visual restoration training. This project will advance both scientific knowledge, as well as technical capability and clinical practices for restoring vision and quality of life for people suffering from cortical blindness.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 25 Feb 2021
- Start date
- 19 Jul 2021
- Primary completion date
- 26 Sept 2025
- Lead sponsor
- University of Rochester
- Diseases
- Stroke
- NCT number
- NCT04798924
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 19 Jul 2021 to the primary completion date, 26 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently use of neuroactive medications which would impact training, as determined by PI
Other illness
- Past or present ocular disease interfering with vision
- History of traumatic brain injury
- Documented history of drug/alcohol abuse
- Cognitive or seizure disorders
Other
- Best corrected visual acuity worse than 20/40 in either eye
- Presence of damage to the dorsal Lateral Geniculate Nucleus, as shown on MRI/CT scans
- Diffuse, whole brain degenerative processes
- Brain damage deemed by study staff to potentially interfere with training ability or outcome measures
- One-sided attentional neglect
- Inability to perform the visual training exercises as directed
Who the study is looking for
- Residents of US and Canada
- MRI and/or CT scans showing evidence of one-sided / unilateral stroke or stroke-like damage to the primary visual cortex or its immediate afferent white matter sustained less than 6-months prior to enrollment
- Reliable visual field defects in both eyes as measured by Humphrey, Macular Integrity Assessment (MAIA), Goldmann, and/or equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
- Ability to fixate on visual targets reliably for 1000ms (as demonstrated by visual fields, and verified in study participation)
- Willing and safely able to undergo magnetic resonance imaging (MRI) scanning
- Willing, able, and competent to provide informed consent
- Fluent in written and spoken English
- Cognitively able, responsible, and willing to complete daily visual training independently at home for several months.
Age in the registry: 21 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.