NCT04804748Recruiting
The DefiPace Study
Safety and Efficacy of Low-energy Electrical Cardioversion With or Without Bi-atrial Pacing in Patients With Post-operative Atrial Fibrillation in a Real World Setting - The DefiPace Study
Source: ClinicalTrials.gov · Last updated 30 Jul 2026
Brief summary (registry, in English)
Prospective, non-interventional, multi-center, international registry in two phases in consecutive patients undergoing elective cardiac surgery. The DefiPace registry is designed in two phases 1. to document the standard of care in 50 patients with atrial fibrillation (AF) 2. to assess the treatment and outcomes of patients with post-operative atrial fibrilllation using low-energy cardioversion and subsequent bi-atrial pacing in clinical practice in 100 patients
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 450 (estimated)
- First submitted
- 16 Mar 2021
- Start date
- 28 Mar 2023
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Institut für Pharmakologie und Präventive Medizin
- Diseases
- Atrial fibrillation
- NCT number
- NCT04804748
What you commit to
- Study type: Observational
- Planned participants: 450
- From 28 Mar 2023 to the primary completion date, 30 Sept 2027
- 10 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Minimally-invasive surgery
- Pregnacy at the time of surgery
Other illness
- Clinical history of either permanent, persistend or paroxysmal atrial fibrillation
- Permanent pacemaker/defibrillator, other intra-cardiac active implanted electronic devices
- Recent stroke within the last 3 months
- A history of or current endocarditis
Who the study is looking for
- Patient is scheduled to undergo elective open chest cardiac surgery (bypass and / or valve surgery)
- Patient is at least 18 years old
- Patient with isolated bypass surgery is at least 70 years old
- Patient with valve surgery is at least 60 years old
- Patient provides written informed consent prior to the procedure
- Phase B only: patient is scheduled for TMA implantation during the elective cardiac surgery and is potentially eligible for DefiPace use
Age in the registry: 18 years to - · Sex: All
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
| Heart Center Dresden GmbH University Hospital Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| Universitätsklinikum Erlangen Coordinator of this site? Confirm its status | Erlangen | Germany | Recruiting |
| Albert-Ludwigs-Universitaet Freiburg Coordinator of this site? Confirm its status | Freiburg im Breisgau | Germany | Recruiting |
| Hannover Medical School Coordinator of this site? Confirm its status | Hanover | Germany | Recruiting |
| University Hospital Jena Coordinator of this site? Confirm its status | Jena | Germany | Recruiting |
| Klinikum Nürnberg Coordinator of this site? Confirm its status | Nuremberg | Germany | Recruiting |
| Oldenburg Hospital AöR / Medical Campus University of Oldenburg Coordinator of this site? Confirm its status | Oldenburg | Germany | Recruiting |
| University Hospital Ulm Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
| University Hospital of Würzburg Coordinator of this site? Confirm its status | Würzburg | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.