NCT04805814Active, not recruiting
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
The Clinical Utility Of Cardiac Magnetic Resonance Imaging in Patients With Angina But No Obstructive Coronary Disease (CorCMR): A Diagnostic Study And Nested Randomised Trial
Source: ClinicalTrials.gov · Last updated 30 Jan 2025
Brief summary (registry, in English)
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected. Recent advances in quantifying myocardial blood flow using stress perfusion cardiac magnetic resonance imaging (CMR) has potential for accurate detection coronary microvascular dysfunction. The CorCMR diagnostic study involves stress perfusion CMR in patients with suspected INOCA to clarify the prevalence of subgroups of patients with underlying problems, such as microvascular disease or undisclosed obstructive coronary artery disease, that might explain their anginal symptoms. A nested, prospective, randomised, controlled, double-blind trial will determine whether stratified medical therapy guided by the results of the stress perfusion CMR improves symptoms, well-being, cardiovascular risk and health and economic outcomes.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 280 (estimated)
- First submitted
- 9 Mar 2021
- Start date
- 9 Feb 2021
- Primary completion date
- 1 Oct 2024
- Lead sponsor
- NHS National Waiting Times Centre Board
- Diseases
- Coronary artery disease
- NCT number
- NCT04805814
What you commit to
- Study type: Interventional
- Planned participants: 280
- From 9 Feb 2021 to the primary completion date, 1 Oct 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Coronary revascularization by percutaneous coronary intervention or coronary artery bypass graft surgery following the index angiogram.
- Prior coronary artery bypass surgery
Other illness
- Obstructive coronary artery disease i.e. a stenosis \>70% in a single segment or 50 - 70% in 2 adjacent segments in an artery \>2.5 mm, or FFR ≤0.80.
- A diagnosis that would explain the angina e.g. anaemia, aortic stenosis, hypertrophic cardiomyopathy,
Lab values
- Contra-indication to contrast-enhanced CMR e.g. eGFR \< 30mL/min/1.73m2.
- Contra-indication to intravenous adenosine, i.e. severe asthma; long QT syndrome; second- or third-degree AV block and sick sinus syndrome.
Other
- Lack of informed consent.
Who the study is looking for
- Age ≥18 years
- Symptoms of angina or angina-equivalent informed by the Rose Angina questionnaire.
- Coronary angiography ≤3 months with a plan for medical management.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Ayr Coordinator of this site? Confirm its status | Ayr | United Kingdom | Unknown status |
| University Hospital Hairmyres Coordinator of this site? Confirm its status | East Kilbride | United Kingdom | Unknown status |
| Golden Jubilee National Hospital Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
Related publications
- Non-invasive endotyping improves treatment satisfaction and prescribing appropriateness in patients with angina and no obstructive coronary artery disease.Open Heart · 2026 · PMID 41997615
- Endotyping-informed therapy for patients with chest pain and no obstructive coronary artery disease: a randomized trial.Nat Med · 2026 · PMID 41214345
This page is information, not medical advice. Discuss any trial with your doctor.