NCT04806412Recruiting
Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
The Prevalence of Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
Source: ClinicalTrials.gov · Last updated 24 Jun 2026
Brief summary (registry, in English)
Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR), so called oncodrivers. These can be measured in pleural fluid, but the prevalence is uncertain. In a prospective study, the research team aim to measure PD-L1, ALK and EGFR in patients with pleural fluid cytology positive for NSCLC to report the prevalence. Also, the study will investigate if the chance of obtaining oncodriver status is depending on the volume analysed and how the lack of oncodrivers influence the following work-up.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 16 Mar 2021
- Start date
- 15 Mar 2021
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Naestved Hospital
- Diseases
- Lung cancer
- NCT number
- NCT04806412
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 15 Mar 2021 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Full oncodriver status measured in any pleural fluid in current work-up
- Inability to understand written or spoken Danish.
Who the study is looking for
- Age ≥ 18 years
- Pleural effusion known or suspected of association with NSCLC (pleural fluid cytology positive for cells from NSCLC)
- Patients must be able to give informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Næstved Sygehus, department of pulmonary medicine Coordinator of this site? Confirm its status | Næstved | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.