NCT04806568Active, not recruiting
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
Cognitive Decline Prognosis in Multiple Sclerosis: Effectiveness of a Computerized Cognitive Training Treatment on Cortical Reorganization
Source: ClinicalTrials.gov · Last updated 21 Sept 2026
Brief summary (registry, in English)
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 3 Mar 2021
- Start date
- 1 Dec 2020
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Aristotle University Of Thessaloniki
- Diseases
- Multiple sclerosis
- NCT number
- NCT04806568
What you commit to
- Study type: Interventional
- Planned participants: 180
- From 1 Dec 2020 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with active chronic disease (or stable but treated with immune therapy) of the immune system other than MS
- Unstable medication within the last 3 months
- Intake of central nervous drugs (e.g., antidepressants)
- Concurrent participation in another relevant study
Other illness
- Patients meeting criteria for other demyelinating diseases of the CNS
- Patients with any other significant CNS disease or serious psychiatric disorder which can interfere with the patient's ability to cooperate or comply with the study procedure
- Any diagnosed neurological, mental, developmental, or psychiatric disorder
- Unrecovered neurological disorders (i.e., stroke, traumatic brain injury)
- Severe physical disorder
Other
- Patients suspected of not being able or willing to cooperate or comply with study protocol requirements
- Patients unable or unwilling to undergo MRI scans and EEG
- Patients unable or unwilling to undergo EEG measurements
Who the study is looking for
- Male/female patients aged 18 to 65 years at screening
- Diagnosis of MS according to the 2017 Revised McDonald criteria
- Disability status at screening with an EDSS score of 0 to 6.5
- Relapsing MS and progressive MS as defined by Lublin
- Neurologically stable within 1 month prior to screening
- Patients receiving the same Disease Modifying Treatment (DMT) for at least 6 months
- Normal hearing and normal or corrected-to-normal vision
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Laboratory of Medical Physics and Digital Innovation, AUTH Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
Related publications
- Preserved α2 oscillations underpin reserve-related resilience of semantic verbal fluency in multiple sclerosis.Front Neurosci · 2026 · PMID 42558982
- Subjective mental fatigue mediates the relationship between information processing speed and verbal memory deficits in multiple sclerosis.Sci Rep · 2026 · PMID 41652001
This page is information, not medical advice. Discuss any trial with your doctor.