NCT04807803Completed
Evaluation of Minimal Hepatic Encephalopathy in Patients With Cirrhosis and Portal Hypertension
Source: ClinicalTrials.gov · Last updated 16 Apr 2026
Brief summary (registry, in English)
Minimal hepatic encephalopathy (MHE) is a subclinical cognitive impairment and represents the mildest type of hepatic encephalopathy (HE). Portal hypertension is the main complication of cirrhosis and is responsible of severe complications such as HE. The consequence of portal hypertension is the formation of the spontaneous portosystemic shunts (SPSS). The relationship between the SPSS and their characteristics and the prevalence of MHE in patient with cirrhosis is poorly known. The main objective of this study is to evaluate the MHE in patients with cirrhosis and portal hypertension.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 82 (actual)
- First submitted
- 16 Mar 2021
- Start date
- 26 Mar 2021
- Primary completion date
- 24 Mar 2025
- Lead sponsor
- IHU Strasbourg
- Diseases
- High blood pressure
- NCT number
- NCT04807803
What you commit to
- Study type: Interventional
- Participants enrolled: 82
- From 26 Mar 2021 to the primary completion date, 24 Mar 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous transjugular intrahepatic portosystemic shunt (TIPS) or surgical shunt.
- Patient in exclusion period of a previous study
Other illness
- Cirrhotic patient with overt HE or history of persistent or recurrent HE.
- Portal vein thrombosis.
- Presence of neurological or psychiatric disorder.
Other
- Hepatocellular carcinoma beyond Milan criteria.
- Patient with treatment by benzodiazepines or opioid substitution.
- Pregnant or nursing women
- Patient under guardianship, trusteeship or the protection of justice or incapable of giving their own informed consent
Who the study is looking for
- Patient with cirrhosis and portal hypertension older than 18 old
- Patient who underwent a CT scan or MRI in the last 3 months
- The Mini-Mental State (MMS) test \>25.
- Patient capable of receiving and understanding information relating to the study and of giving his written informed consent.
- Patient affiliated to the French social security system
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service d'Hépato-Gastroentérologie, Hôpitaux Civils Coordinator of this site? Confirm its status | Colmar | France | Unknown status |
| Service d'Hépato-gastroentérologie, NHC Coordinator of this site? Confirm its status | Strasbourg | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.