NCT04810858Recruiting
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 220 (estimated)
- First submitted
- 16 Mar 2021
- Start date
- 18 Aug 2021
- Primary completion date
- 31 May 2027
- Lead sponsor
- Wake Forest University Health Sciences
- Diseases
- HIV
- NCT number
- NCT04810858
What you commit to
- Study type: Interventional
- Planned participants: 220
- From 18 Aug 2021 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Lifetime abuse for any illicit drug other than marijuana
- immunotherapy
Other illness
- history of moderate or severe head trauma
- unstable or serious neurological disorders
- severe mental illness
- systemic autoimmune diseases
Other
- \<9th grade education; illiteracy or lack of fluency in English
- MRI contraindications
Who the study is looking for
- verified HIV status
- Current marijuana use (MJ+ groups only)
- No current marijuana use (MJ- groups only)
- current engagement in HIV care (HIV+ participants only)
- receipt of cART as first-line of treatment (HIV+ participants only)
- stable cART regimen (HIV+ participants only)
- undetectable HIV RNA viral load for \>1 year (HIV+ participants only)
Age in the registry: 25 years to 59 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Biotech Place Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.