NCT04815824Completed
Exercise Mode and Acute Bone Resorption
Comparison of Exercise Mode on Disruptions in Calcium Homeostasis
Source: ClinicalTrials.gov · Last updated 20 Jul 2025
Brief summary (registry, in English)
Endurance exercise is often recommended to improve cardiometabolic health and maintain bone health throughout life and to prevent osteoporotic fracture. However, there is evidence to suggest that bone does not always adapt in the way that is expected, and that endurance exercise may lead to bone loss under certain conditions. Disruptions in calcium homeostasis during exercise may explain this observation, and preliminary data suggests that the mode of exercise (i.e., cycling versus treadmill) may result in different magnitudes of change in bone biomarkers. The purpose of this study is to determine if mode of exercise results in a differential bone biomarker response to an acute exercise bout in older Veterans. Blood samples will be collected before, during, and after 2 acute exercise bouts: 1) brisk treadmill walking; and 2) vigorous stationary cycling. Bouts will be matched for relative intensity and duration. This data will be used to develop future exercise interventions in older Veterans aimed at preserving both cardiometabolic and bone health.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 9 (actual)
- First submitted
- 22 Mar 2021
- Start date
- Oct 2021
- Primary completion date
- Jun 2024
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Osteoporosis
- NCT number
- NCT04815824
What you commit to
- Study type: Interventional
- Participants enrolled: 9
- From Oct 2021 to the primary completion date, Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg
- history of type 1 or type 2 diabetes
- cardiovascular disease; defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT)
- volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist
Lab values
- hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal
- serum Ca \<8.5 or \>10.3 mg/dL; 5) serum 25(OH)D \<20 ng/mL
- anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men
- current diagnosis or symptoms of COVID-19
- In the event of abnormal BP, live function, TSH, 25(OH)D, or hemoglobin values, volunteers can be reassessed, including after appropriate follow-up evaluation and treatment by a primary care provider
- Those who have experienced symptoms of COVID-19 or have been formally diagnosed will be allowed to participate once symptoms have resolved and they are approved to return to exercise by their primary care provider
Other
- impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2;(Florkowski and Chew-Harris 2011)
- thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L
- fracture in the past 6 months
Who the study is looking for
- Healthy older (60+ y) Veteran women and men will be eligible to participate
- All volunteers must be accustomed to performing 60 minutes of vigorous cycling and treadmill exercise
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rocky Mountain Regional VA Medical Center, Aurora, CO Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.