NCT04820335Completed
Promoting Independence With Compensatory Cognitive Rehabilitation
Promoting Independence With Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
Alzheimer's disease (AD) is one of the leading causes of disability in older adults. Because pharmacological approaches do not seem to prevent or slow the disease, clinicians need non-pharmacological interventions that might help people with AD remain independent for as long as possible. This study aims to evaluate the effects of a new behavioral treatment, the Structured External Memory Aid Treatment (SEMAT), for adults with mild cognitive impairment (MCI) designed to promote independent living skills by explicitly teaching the use of strategies and tools to compensate for cognitive weaknesses. Aim 1: Evaluate the efficacy of the SEMAT for improving functional performance in a pilot randomized trial. Aim 2: Evaluate demographic, clinical, and neuropsychological predictors of treatment adherence. Aim 3: Develop and refine the SEMAT manual and other materials for training future interventionists.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 68 (actual)
- First submitted
- 17 Mar 2021
- Start date
- 1 Feb 2022
- Primary completion date
- 15 Sept 2025
- Lead sponsor
- University of Delaware
- Diseases
- Alzheimer disease
- NCT number
- NCT04820335
What you commit to
- Study type: Interventional
- Participants enrolled: 68
- From 1 Feb 2022 to the primary completion date, 15 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of major psychiatric disorder (e.g. schizophrenia)
- History of medical diseases that are related to cognitive impairment
- major auditory, visual, or motor impairment that would affect their ability to participate in the study
- substance use disorder in the past 5 years
Other
- Untreated major depression
- current participation in another clinical trial related to memory
Who the study is looking for
- 60-90 years of age
- English Speaking
- Functional Vision and Hearing to Complete Phone Screen
- not taking or stable ( \>2 months) on nootropic meds
- amnestic mild cognitive impairment from probable Alzheimer's disease
Age in the registry: 60 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Delaware Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.