NCT04829071RecruitingEarly phase 1
Cognition and Motor Learning Post-stroke
Cognition as a Moderator of Motor Learning Post-stroke
Source: ClinicalTrials.gov · Last updated 4 Nov 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 65 (estimated)
- First submitted
- 30 Mar 2021
- Start date
- 16 Jan 2023
- Primary completion date
- 14 Aug 2026
- Lead sponsor
- University of Southern California
- Diseases
- Stroke
- NCT number
- NCT04829071
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 65
- From 16 Jan 2023 to the primary completion date, 14 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent physical therapy
Other illness
- Brainstem or cerebellar stroke
- Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
- Uncontrolled hypertension (\>160/110mmHg)
- Significant cognitive deficit or dementia (\<20 on MoCA)
Other
- Aphasia (expressive, receptive, or global)
- Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
- Claustrophobia
- Inability to give informed consent
Who the study is looking for
- Unilateral stroke
- Stroke occurred more than 6 months prior
- Paresis confined to one side
- Independently ambulatory (including the use of assistive devices)
- Able to walk for 5 minutes without stopping
- Answers no to all general health questions on the PAR-Q+
- Willingness to complete study procedures
Age in the registry: 45 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Center for Health Professions Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.