NCT04840342CompletedPhase 4
MR Antagonist and LSD1
Role of LSD1 in Hypertension in Blacks
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks. This project investigates whether a genetically driven anti-hypertensive approach proves superior in controlling blood pressure and mitigating renal injury in Blacks who carry the risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new approach in treating a subset (\~30%) of the essential hypertension population (Black LSD1 risk allele hypertensives).
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 300 (actual)
- First submitted
- 7 Apr 2021
- Start date
- 3 Feb 2022
- Primary completion date
- 15 Sept 2025
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- High blood pressure
- NCT number
- NCT04840342
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 300
- From 3 Feb 2022 to the primary completion date, 15 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- any drug therapy, except for anti-hypertensives and stable thyroid medication replacement
Other illness
- known cardiac disease other than HTN
- renal, circulatory or neurologic diseases
- diabetes
Other
- smoking
- secondary HTN as indicated by history, physical examination or screening blood and urine tests
- smoking
Who the study is looking for
- untreated as well as currently treated hypertensives
- rs587168 allele carriers
- not on more than two anti-hypertensives
- normal renal, metabolic, electrolyte, and CBC laboratory tests
- self-identified Black race
- age \>17 yrs.
Age in the registry: 17 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.