NCT04844684Recruiting
Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients
Link Between the Metabolism of Cortisol and Bile Acids in Obese Patients Before and After Bariatric Surgery
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
Bariatric surgery is currently the most efficient treatment for obesity. The sustained weight loss and metabolic improvement seen following Roux-en-Y gastric bypass (RYGB), is explained partly by modifications in hormones including bile acids (BA). After RYGB, an increased total BA pool and a reduction in hepatic cortisol exposure is observed. Hydroxysteroid 11-β dehydrogenase 1 (HSD11B1), steroid 5α-reductases (SRD5A), and steroid 5β-reductases, AKR1D1 (also a BA metabolizing enzyme), are three enzymes involved in the metabolism of cortisol in the liver and are known to participate in metabolic syndrome. Their activity has been shown to be decreased after RYGB. Interestingly, the mechanisms explaining the modification of hepatic cortisol exposure and the activity of theses enzymes after RYGB are unknown. In view of the few data suggesting a link between cortisol metabolism and bile acids, this work aim to study and characterize this link in a context of RYBP
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 13 Apr 2021
- Start date
- 30 Mar 2023
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- University Hospital, Lille
- Diseases
- Obesity
- NCT number
- NCT04844684
What you commit to
- Study type: Observational
- Planned participants: 30
- From 30 Mar 2023 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- moderate and severe kidney insufficiency
- hepatic insufficiency
- history of cholecystectomy or cholecystectomy planned during the gastric bypass
- history of bariatric surgery except gastric band and gastric balloon
- history of type 1
Other
- known gallbladder lithiasis
- treatment interfering with the cortisol metabolism: taking oral or inhaled glucocorticoids within the last 6 months
- treatment by BA as ursodeoxycholic acid, bile acids sequester, statin, fibrate stopped less than 4 weeks ago
Who the study is looking for
- Non-menopausal women
- BMI between 35 and 50 kg/m² included
- Social insured
- Ability to give consent
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Huriez - Service d'endocrinologie, diabétologie, nutrition et métabolisme Coordinator of this site? Confirm its status | Lille | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.