NCT04844931Active, not recruiting
Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction
Randomized Comparison of Combined Remote Ischemic Conditioning and Local Postconditioning Compared to Standard Treatment in High-risk ST-elevation Myocardial Infarction Patients
Source: ClinicalTrials.gov · Last updated 13 Mar 2025
Brief summary (registry, in English)
The RIP-HIGH trial is a two-arm randomized controlled trial aiming to compare the impact of combined remote ischemic conditioning (RIP) and local ischemic postconditioning (PostC) vs. standard of care on clinical outcome in high-risk ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 250 (actual)
- First submitted
- 31 Mar 2021
- Start date
- 5 Jul 2021
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Helios Health Institute GmbH
- Diseases
- Coronary artery disease
- NCT number
- NCT04844931
What you commit to
- Study type: Interventional
- Participants enrolled: 250
- From 5 Jul 2021 to the primary completion date, 31 Dec 2025
- 11 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior fibrinolysis.
Other illness
- Conditions precluding use of RIC (i.e. paresis of the upper limb, presence of an arteriovenous shunt).
Age
- Age \<18 years.
Other
- Killip class I on hospital admission.
- Pregnancy.
- Severe co-morbidity with a life expectancy \<6 months.
- Participation in another trial.
Who the study is looking for
- Acute chest pain lasting \<12 h
- ST-elevation at the J-point in two contiguous leads of ≥2 mm in men ≥40 years, ≥2.5 mm in men \<40 years and ≥1.5 mm in women (regardless of age) in V2-V3 and/or ≥1 mm in all other leads (52).
- New or presumed new left bundle branch block or right bundle branch block.
- Killip class ≥II on hospital admission or requirement of diuretics because of clinical congestion.
- Written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (11)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medizinische Universität Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Unknown status |
| Klinikum Links der Weser Coordinator of this site? Confirm its status | Bremen | Germany | Unknown status |
| Herzzentrum Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| Universitätsklinikum Düsseldorf Coordinator of this site? Confirm its status | Düsseldorf | Germany | Unknown status |
| University Hospital Essen Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| University Clinic Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| University Heart Center Lübeck - University of Schleswig-Holstein Coordinator of this site? Confirm its status | Lübeck | Germany | Unknown status |
| Klinikum Ludwigshafen Coordinator of this site? Confirm its status | Ludwigshafen | Germany | Unknown status |
| Universitätsmedizin Rostock Coordinator of this site? Confirm its status | Rostock | Germany | Unknown status |
| University Hospital Tübingen Coordinator of this site? Confirm its status | Tübingen | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.