NCT04845529Not yet recruiting
Improving Awareness for Spatial Neglect With tDCS
Improving Awareness in Right-brain-damaged Patients With Unilateral Spatial Neglect Using Transcranial Direct Current Stimulation (tDCS)
Source: ClinicalTrials.gov · Last updated 30 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Brain-damaged patients can show severe neurological and cognitive deficits, and yet often remain strikingly unaware of these symptoms: this condition is called anosognosia. The aim of this study is to improve awareness in right-brain-damaged patients with Unilateral Spatial Neglect (USN) following stroke using transcranial direct current stimulation (tDCS). tDCS is a neuromodulatory technique that delivers low-intensity current to the brain facilitating (anodal tDCS) or inhibiting (cathodal tDCS) spontaneous neuronal activity. tDCS does not induce activity in resting neuronal networks, but modulates spontaneous neuronal activity: consequently, the amount and direction of effects critically depend on the previous state of the neural structures. We will test USN patients showing anosognosia for neglect symptoms. Different brain areas will be stimulated, to target explicit and implicit components of anosognosia, including parietal and frontal brain regions.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 30 Mar 2021
- Start date
- Dec 2026
- Primary completion date
- Jan 2027
- Lead sponsor
- University of Geneva, Switzerland
- Diseases
- Stroke
- NCT number
- NCT04845529
What you commit to
- Study type: Interventional
- Planned participants: 12
- From Dec 2026 to the primary completion date, Jan 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Precedent additional neurological disorder and/or current or precedent psychiatric disease
- Presence of one or more exclusion criteria for the electrical brain stimulation 18, as following:
- Presence (or suspected presence) of metal in the brain or skull or body (except titanium) (e.g. splinters, fragments, clips, etc.) Presence of cochlear implants, implanted neuro-stimulator (e.g., DBS, epidural/subdural, VNS), cardiac pacemaker, medication infusion device, spinal or ventricular derivations Presence of epilepsy (participant and/or the close family) and/or precedent epileptic seizures (participant) Presence of a fainting spell or syncope, due to neurological diseases (not consider syncope during blood sampling or after being in a warm environment or after emotionally stressful events) Presence of a severe (i.e., followed by loss of consciousness) head trauma Presence of hearing problems or ringing in your ears (e.g. tinnitus) Current treatment under psychoactive (e.g. antidepressants, tranquilizers) or antiepileptic medications Chronic headache For women: you are pregnant or there is any chance that you might be.
Other
- Presence of general cognitive deficits and/or suspicious of possible cognitive deficits
- Presence of difficulty in task's comprehension
- Impossibility to sustain a research session of at least 45minutes (e.g., attentional lability)
Who the study is looking for
- First stroke affecting the right-hemisphere
- Presence of USN, as assessed by a standard neuropsychological evaluation
- Structural images of the brain lesion available (magnetic resonance or tomographic scans)
- Criteria for electrical brain stimulation
- Good (or corrected) visual acuity
- High proficiency in French
- Right-handed
Age in the registry: 20 years to 85 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.