Fact CheckerSign in

NCT04858568Completed

Immune Responses to COVID-19 Vaccination in Lymphoma Patients

PROSECO - A UK Multicentre Prospective Observational Study Evaluating COVID-19 Vaccine Immune Responses in Lymphoid Cancer

Source: ClinicalTrials.gov · Last updated 6 Feb 2024

Brief summary (registry, in English)

This prospective observational study aims to evaluate the robustness and persistence of immune responses to vaccination, define factors associated with impaired immune responses and assess the incidence of COVID-19 infections in vaccinated individuals. To do this, we will collect peripheral blood from patients with lymphoid cancers before and after their COVID-19 vaccination. The blood will be explored in the laboratory for antibodies to SARS-CoV-2 and T-cell responses to the spike protein. Detailed clinical information will also be collated on about their cancer and treatment.

Status (registry)
Completed
Study type
Observational
Enrollment
592 (actual)
First submitted
22 Apr 2021
Start date
11 Mar 2021
Primary completion date
31 Oct 2022
Lead sponsor
University Hospital Southampton NHS Foundation Trust
NCT number
NCT04858568

What you commit to

  • Study type: Observational
  • Participants enrolled: 592
  • From 11 Mar 2021 to the primary completion date, 31 Oct 2022
  • 9 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • 1\) Serious medical or psychiatric illness likely to affect participation or that may compromise the ability to give informed consent.

Who the study is looking for

  • Patients having a confirmed diagnosis of either:
    • Hodgkin lymphoma B) Aggressive B-cell lymphoma (e.g. Burkitt's lymphoma, diffuse large B-cell lymphoma, grade 3b follicular lymphoma, de novo transformed follicular lymphoma) C) Indolent B-cell lymphoma (e.g. all grades of follicular lymphoma except grade 3b, marginal zone lymphoma, lymphoplasmacytic lymphoma, chronic or small lymphocytic lymphoma, mantle cell lymphoma) D) Mature T/NK-cell malignancy (any subtype)
  • Patient must be ≥ 18 years.
  • Patients will have provided written Informed Consent.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (9)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Bedfordshire Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
BedfordUnited KingdomUnknown status
Wye Valley NHS Trust
Coordinator of this site? Confirm its status
HerefordUnited KingdomUnknown status
University Hospitals of Leicester NHS Trust
Coordinator of this site? Confirm its status
LeicesterUnited KingdomUnknown status
The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
Newcastle upon TyneUnited KingdomUnknown status
Norfolk and Norwich University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
NorwichUnited KingdomUnknown status
Nottingham University Hospitals NHS Trust
Coordinator of this site? Confirm its status
NottinghamUnited KingdomUnknown status
Oxford University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
OxfordUnited KingdomUnknown status
Portsmouth Hospitals University NHS Trust
Coordinator of this site? Confirm its status
PortsmouthUnited KingdomUnknown status
University Hospital Southampton NHS Foundation Trust
Coordinator of this site? Confirm its status
SouthamptonUnited KingdomUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.