NCT04858568Completed
Immune Responses to COVID-19 Vaccination in Lymphoma Patients
PROSECO - A UK Multicentre Prospective Observational Study Evaluating COVID-19 Vaccine Immune Responses in Lymphoid Cancer
Source: ClinicalTrials.gov · Last updated 6 Feb 2024
Brief summary (registry, in English)
This prospective observational study aims to evaluate the robustness and persistence of immune responses to vaccination, define factors associated with impaired immune responses and assess the incidence of COVID-19 infections in vaccinated individuals. To do this, we will collect peripheral blood from patients with lymphoid cancers before and after their COVID-19 vaccination. The blood will be explored in the laboratory for antibodies to SARS-CoV-2 and T-cell responses to the spike protein. Detailed clinical information will also be collated on about their cancer and treatment.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 592 (actual)
- First submitted
- 22 Apr 2021
- Start date
- 11 Mar 2021
- Primary completion date
- 31 Oct 2022
- Lead sponsor
- University Hospital Southampton NHS Foundation Trust
- Diseases
- Diffuse large B-cell lymphoma, Follicular lymphoma, Hodgkin lymphoma, Mantle cell lymphoma, Chronic lymphocytic leukaemia
- NCT number
- NCT04858568
What you commit to
- Study type: Observational
- Participants enrolled: 592
- From 11 Mar 2021 to the primary completion date, 31 Oct 2022
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 1\) Serious medical or psychiatric illness likely to affect participation or that may compromise the ability to give informed consent.
Who the study is looking for
- Patients having a confirmed diagnosis of either:
- Hodgkin lymphoma B) Aggressive B-cell lymphoma (e.g. Burkitt's lymphoma, diffuse large B-cell lymphoma, grade 3b follicular lymphoma, de novo transformed follicular lymphoma) C) Indolent B-cell lymphoma (e.g. all grades of follicular lymphoma except grade 3b, marginal zone lymphoma, lymphoplasmacytic lymphoma, chronic or small lymphocytic lymphoma, mantle cell lymphoma) D) Mature T/NK-cell malignancy (any subtype)
- Patient must be ≥ 18 years.
- Patients will have provided written Informed Consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bedfordshire Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Bedford | United Kingdom | Unknown status |
| Wye Valley NHS Trust Coordinator of this site? Confirm its status | Hereford | United Kingdom | Unknown status |
| University Hospitals of Leicester NHS Trust Coordinator of this site? Confirm its status | Leicester | United Kingdom | Unknown status |
| The Newcastle Upon Tyne Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Unknown status |
| Norfolk and Norwich University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Norwich | United Kingdom | Unknown status |
| Nottingham University Hospitals NHS Trust Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
| Oxford University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Portsmouth Hospitals University NHS Trust Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Unknown status |
| University Hospital Southampton NHS Foundation Trust Coordinator of this site? Confirm its status | Southampton | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.