Photodynamic Therapy for Cholangiocarcinoma

Prior treatment

• Other photosensitizers have been used within 4 weeks prior；
• Metal biliary stents were placed previously；
• Patients with other contraindications for photodynamic therapy.

Other illness

• known to allergic to study drug(porphyrin drugs) or other similar and related compounds；
• Patients with HIV infection；
• Patients complicated with other malignant tumors；
• Patients with other serious physical or mental illnesses that prevent researchers to enroll them in this study as subjects；

Lab values

• Coagulation dysfunction (INR\> 1.5) and low peripheral blood platelet count(\<50×10\^9 / L) or using anti-coagulation drugs；
• Bilirubin could not be reduced to less than 100mmol/L within 1 month after drainage；

Other

• Proximal cholangiocarcinoma (Bismuth type Ⅲ-Ⅳ, or intra-hepatic cholangiocarcinoma);
• Patients with Karnofsky Performance Scale (KPS) score≤70；
• Expected survival≤3months；
• Patients with porphyria；
• Patients have intrahepatic metastasis or distant metastasis；
• Patients with no pathological diagnosis；
• Patients with contraindications to ERCP；
• Pregnant, parturient, or breastfeeding women；
• Patients with severe liver function damage；
• Patients who were in cachexia, liver abscess, or advanced patients who were unable to tolerate PDT；

• ERCP cholangiocarcinoma（the tumor is unresectable or patient can't accept surgery in the situation, the tumor can be resected but the patients cannot tolerate surgery）;