NCT04862273Completed
CMR T1 Mapping for Diagnosis of Cardiac Amyloidosis
Native T1 Cardiac Magnetic Resonance Imaging for Diagnosis of Cardiac Amyloidosis
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
The study aims to test the diagnostic accuracy of T1 mapping for the diagnosis of cardiac amyloidosis prospectively. The hypothesis is that T1 mapping in older patients with symptomatic heart failure, increased LV wall thickness and elevated cardiac biomarkers is non-inferior to the reference method to diagnose cardiac amyloidosis (CA). As secondary measure, a web-based ATTR probability estimator for the diagnosis of CA will be evaluated.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 112 (actual)
- First submitted
- 20 Apr 2021
- Start date
- 1 Apr 2021
- Primary completion date
- 1 Mar 2023
- Lead sponsor
- University of Leipzig
- Diseases
- Amyloidosis, Heart failure
- NCT number
- NCT04862273
What you commit to
- Study type: Observational
- Participants enrolled: 112
- From 1 Apr 2021 to the primary completion date, 1 Mar 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Acute myocardial infarction \<1 month
Other
- Contraindications for CMR
- Acute myocarditis
- Severe aortic stenosis and RAISE score \< 2 points
Who the study is looking for
- Age ≥ 60 years
- Symptomatic heart failure (NYHA II-IV) with LVEF ≥40%
- Increased LV wall thickness (≥12mm end-diastolic)
- NT-proBNP ≥1000pg/mL
- Elevated hs-troponin T ≥14ng/L
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
Related publications
- Cardiac magnetic resonance T1 mapping for amyloid cardiomyopathy in patients with heart failure.Eur Heart J Imaging Methods Pract · 2026 · PMID 42662629
This page is information, not medical advice. Discuss any trial with your doctor.