NCT04865965Completed
Effects of a Single Bout of Exercise on Transcriptomics and Metabolomics in Adipose Tissue
Source: ClinicalTrials.gov · Last updated 24 Feb 2025
Brief summary (registry, in English)
The purpose of this study is to determine the effects of a single bout of exercise on changes in the genes and small molecules in blood and fat tissue, before and after a bout of exercise. This research may contribute to a better understanding of the beneficial effects of exercise on the body.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 13 Apr 2021
- Start date
- 27 May 2021
- Primary completion date
- 23 May 2024
- Lead sponsor
- Joslin Diabetes Center
- Diseases
- Obesity
- NCT number
- NCT04865965
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 27 May 2021 to the primary completion date, 23 May 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of weight loss medications (i.e. GLP-1 agonists)
- Acute infection, including COVID-19 (current or recent infection of COVID-19 in the previous 3 months)
Other illness
- Use of any medications related to diabetes
- Heart or lung disease
- Any hospitalization due to COVID-19.
- Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
Lab values
- Blood glucose rises ≥140mg/dl at 2 hours after OGTT on Visit 1
- Use of agents that affect hepatic glucose production such as beta adrenergic agonists, xanthine derivatives
Other
- Exercises frequently i.e. ≥ 150 minutes per week of moderate intensity or ≥ 75 min high intensity.
- Use of beta-blockers
- Use of anticoagulation and aspirin
- Currently pregnant or breastfeeding
- Current smoker
- Inability to exercise for any reason
- Any known contraindication to exercise testing based on current ACSM guidelines (5)
Who the study is looking for
- Age 20-60 years
- Body mass index (BMI) ≥30.0 ± 0.1 and ≤40.0 ± 0.1 kg/m2
- HbA1c ≤ 5.7 ± 0.1%
- No history of diabetes (type 1 and type 2)
- In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
- Willing to adhere to the protocol requirements for the duration of the study
Age in the registry: 20 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Joslin Diabetes Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.