NCT04875936Recruiting
Neurofeedback Intervention for Reading Deficits in Subacute Stroke
Rehabilitation of Reading Deficits in Subacute Stroke Using Functional Magnetic Resonance Imaging (fMRI) Neurofeedback and Motor Imagery
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 28 (estimated)
- First submitted
- 29 Apr 2021
- Start date
- 3 Apr 2023
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Kessler Foundation
- Diseases
- Stroke
- NCT number
- NCT04875936
What you commit to
- Study type: Interventional
- Planned participants: 28
- From 3 Apr 2023 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)
- A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)
Other
- Inability to consent or complete study tasks
Who the study is looking for
- First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer
- Age: 18 - 80 years old
- Fluent and literate in English prior to stroke
- Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kessler Foundation Coordinator of this site? Confirm its status | West Orange | United States | Recruiting |
Related publications
- Feasibility Randomized Controlled Trial of Real-Time fMRI Neurofeedback for Reading Rehabilitation in Aphasia.Stroke · 2026 · PMID 41958417
This page is information, not medical advice. Discuss any trial with your doctor.