Fact CheckerSign in

NCT04876404Completed

Somatotopy in Parkinson's Disease

Somatotopy and Striatal Plasticity in Parkinson's Disease

Source: ClinicalTrials.gov · Last updated 26 Oct 2024

Brief summary (registry, in English)

This study aims to assess changes in connections within the brain in Parkinson's disease (PD). We will invite up to 10 people with PD to participate in this study and complete several brain scans using PET (Positron Emission Tomography) and fMRI (functional Magnetic Resonance Imaging) on the Hybrid PET/MRI scanner. We will also invite 10 participants without PD to complete the same scans for comparison. "Somatotopy" refers to how areas of the brain are organized according to the body part they affect. The striatum is the brain region that coordinates complex thinking and movement. Plasticity refers to changes in connections within the brain, which can happen to make up for changes that are related to PD. In this study we will use PET and fMRI imaging together to investigate changes in the striatum in people affected by Parkinson's disease. The hybrid PET/MR scanner allows us to perform simultaneous PET and MRI measurements to investigate this.

Status (registry)
Completed
Study type
Observational
Enrollment
30 (actual)
First submitted
3 May 2021
Start date
25 Jan 2021
Primary completion date
27 Nov 2023
Lead sponsor
Pacific Parkinson's Research Centre
NCT number
NCT04876404

What you commit to

  • Study type: Observational
  • Participants enrolled: 30
  • From 25 Jan 2021 to the primary completion date, 27 Nov 2023
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Ear or eye implant;
  • Implanted drug infusion pump;
  • Surgery (brain or otherwise), tattoos or injection into a join in the last 6 weeks

Other illness

  • Current or past major psychiatric disorders (e.g. depression, anxiety disorders) or other major neurological disease ii. Current or past substance use problems iii. Serious head injury with loss of consciousness for ≥ 5 minutes iv. Fear of enclosed, confined spaces v. Pregnant or breastfeeding vi. Presence of active, recent, or repeated cancer vii. Unstable/undiagnosed medical conditions viii. Certain medications or conditions may impact the ability to participate and these will be discussed on a case by case basis with the study team.
  • Cardiac pacemaker, wires or defibrillator;
  • Artificial heart valve;

Other

  • Weight of more 158 kg x. Inability to remain still during the scans. xi. People for whom MRI is contra-indicated:
  • People with a non-MRI safe intrauterine device (IUD);
  • Machinist or Metalworkers;
  • Past injury where a piece of metal lodged in your eye or orbit;
  • Ferromagnetic aneurysm clip;
  • Brain aneurysm clip;
  • Electrical stimulator for nerves or bones or brains;
  • Coil, catheter, or filter in any blood vessel;
  • Orthopaedic hardware (artificial joint, plate, screws);
  • Other metallic prostheses;
  • Shrapnel, bullets, or other metal fragments;

Who the study is looking for

  • Recently diagnosed with early stage Parkinson's Disease (within 5 years of diagnosis) ii. Between the ages of 50 to 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study
    • Healthy Control Individuals
  • Healthy male between the ages of 50 and 85 ii. Healthy female between the ages of 50 and 85 iii. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study

Criteria the registry did not label

  • Parkinson's Disease Individuals

Age in the registry: 50 years to 85 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
UBC Pacific Parkinson's Research Centre
Coordinator of this site? Confirm its status
VancouverCanadaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.