NCT04878445Active, not recruiting
Tissue Engineering Approaches to Treat COPD
A Tissue Engineering Approach to Improve Lung Function and Clinical Outcome in Patients With COPD
Source: ClinicalTrials.gov · Last updated 4 Feb 2025
Brief summary (registry, in English)
The study is a pilot/laboratory study comparing lung tissue from control participants with tissue from COPD participants with a chronic bronchitis or emphysema phenotypes. Tissue will be characterised mechanically and biochemically. Lung cells, including DASCp63/Krt5 with a possible role in disease pathology, will be isolated, expanded in vitro, characterised, and banked. Biomaterials will be selected and tested with regards to mechanical and physical properties and selected for use in the production of TELEs with properties matched to healthy and diseased lung tissue. The resulting TELEs will be tested in an ex vivo tissue culture model to determine the extent of their integration with lung.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 30 Apr 2021
- Start date
- 31 Aug 2017
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- University Hospitals of North Midlands NHS Trust
- Diseases
- Lung cancer
- NCT number
- NCT04878445
What you commit to
- Study type: Observational
- Planned participants: 30
- From 31 Aug 2017 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Significant long term condition or lung pathology (infection, asthma, fibrotic lung diseases) other than that for which they have been referred for surgery.
- Post Surgery
Lab values
- Insufficient tissue removed to supply the laboratory study after consultation with the Consultant histopathologist.
Other
- Patient unable to give informed consent
Who the study is looking for
- Men or women aged over 18 years- .
- Must be competent to give written informed consent.
- Scheduled to undergo clinical indicated surgery to remove lung tissue.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals of North Midlands NHS Trust Coordinator of this site? Confirm its status | Stoke-on-Trent | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.