NCT04881487Recruiting
Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
A Randomized Controlled Trial on Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
A randomized controlled trial, nested within an existing prospective cohort (Dutch Pancreatic Cancer Project; PACAP) according to the 'trials within cohorts' (TwiCs) design in which the effect of additional local ablative therapy compared to current standard of care alone, on survival after recurrence in patients with isolated local pancreatic ductal adenocarcinoma (PDAC) recurrence. The most important secondary endpoint is quality of life. Other secondary endpoints are treatment response, acute and late toxicity, overall survival, progression-free survival, local progression-free survival, distant metastases free survival and reasons for non-eligibility or exclusion.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 174 (estimated)
- First submitted
- 25 Mar 2021
- Start date
- 5 Jul 2021
- Primary completion date
- Aug 2026
- Lead sponsor
- UMC Utrecht
- Diseases
- Pancreatic cancer
- NCT number
- NCT04881487
What you commit to
- Study type: Interventional
- Planned participants: 174
- From 5 Jul 2021 to the primary completion date, Aug 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Highly selective cases with resectable, isolated local recurrence without the need for either systemic or local ablative induction therapy, eligible for re-resection according to the expert panel.
Other
- Distant metastases
- Expected lifespan \< 3 months
- Ineligibility for MRI or CT according to the protocol of the local radiology department;
Who the study is looking for
- Participation in the PACAP cohort with written informed consent for being randomized in future studies
- Isolated local recurrence after primary PDAC resection
- Minimum age of 18 years
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amsterdam University Medical Center, VUmc Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Erasmus University Medical Center Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| University Medical Center Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.