NCT04886128Completed
Improving Diagnostic Accuracy for Acute Heart Failure
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs. The current diagnostic approach to acute heart failure has modest accuracy, leading to delayed diagnosis and treatment, which associate with worse prognosis. Prior work suggests diagnostic accuracy can be improved with the addition of multiple circulating biomarkers discovered through proteomics, and this study will derive and validate a multi-marker model to improve diagnostic accuracy for acute heart failure in the emergency department.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 2469 (actual)
- First submitted
- 4 May 2021
- Start date
- 31 Aug 2021
- Primary completion date
- 1 May 2026
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Heart failure
- NCT number
- NCT04886128
What you commit to
- Study type: Observational
- Participants enrolled: 2469
- From 31 Aug 2021 to the primary completion date, 1 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of end-stage renal disease for which hemodialysis is needed
- Dyspnea due to primary presentation of an acute coronary syndrome or trauma
Who the study is looking for
- Willing to adhere to the study protocol
- Able to provide written consent
- English or Spanish speaking
- Adult, defined as 18 years or older
- Primary reason for presentation to the ED is dyspnea
- ED physician is considering a diagnosis of HF, defined by ordering a NP test and/or a chest x-ray
Criteria the registry did not label
- For enrollment into the prospective cohort for Outcome 3.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.