NCT04888364Recruiting
French Parkinson's Disease Cohort - NS-PARK
Cohort of the French Clinical Research Network for Parkinson's Disease (NS-PARK Cohort)
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
The aim of NS-PARK cohort are to describe the natural history of Parkinson's disease (PD), and to propose patients stratification models based on PD pathophysiological mechanisms. Patients are included at all PD expert centers in France. Standardized demographic, diagnosis, motor and non-motor symptoms evaluation, and treatment information are collected, and clinical data are updated at each visit of the patient at the center. A blood sampling is perform at baseline for genetic testing and implement an associated biocollection.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30000 (estimated)
- First submitted
- 19 Apr 2021
- Start date
- 16 Jun 2021
- Primary completion date
- 31 Dec 2032
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Diseases
- Parkinson disease
- NCT number
- NCT04888364
What you commit to
- Study type: Observational
- Planned participants: 30000
- From 16 Jun 2021 to the primary completion date, 31 Dec 2032
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Subject under legal protection
- Subject who do not consent to the research
- for the optional skin biopsy only: clinically significant coagulation abnormalities or anticoagulant treatment
Who the study is looking for
- Diagnosis of Parkinson's disease according to UK PD brain bak criteria
- OR diagnosis of parkinsonian syndrome: multiple system atrophy, progressive supranuclear palsy, dementia with Lewy body, or corticobasal syndrom
- OR Subjects at risk of PD defined as :
- No symptom or diagnosis of Parkinson's disease nor parkinsonian syndrome, and relative to a patient with a diagosis of PD or parkinsonian syndrome, or carrier of a known mutation responsible for a genetic form of PD or patient with a diagnosis of idiopathic REEM sleep disorder or prodromal form of PD as defined by MDS criteria (Berg et al., 2015)
- AND for all participants
- Affiliated to social security
- Age \> 10 years
Age in the registry: 10 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre 01 Paris Coordinator of this site? Confirm its status | Paris | France | Recruiting |
Related publications
- Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson's disease.Neurobiol Dis · 2026 · PMID 41455502
This page is information, not medical advice. Discuss any trial with your doctor.