NCT04902352Active, not recruiting
The DISSECT Study: Effect of Peri-aDventItial SMA diSsECtion on Margin sTatus During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
Effect of Peri-adventitial SMA Dissection on Margin Status During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
There is a high rate of R1 resection following patients undergoing pancreaticoduodenectomy for pancreatic cancer. The most commonly positive margin is the SMA. Peri-adventitial dissection has been proposed as an effective method of achieving R0 margins. There is lack of standardisation of the proposed technique and no grade 1 evidence to support routine use of this technique. The goal of this randomised controlled trial is to investigate the role of routine peri-adventitial dissection on the SMA margin status.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 102 (estimated)
- First submitted
- 13 May 2021
- Start date
- 6 Apr 2021
- Primary completion date
- 6 Oct 2026
- Lead sponsor
- University Hospital Birmingham NHS Foundation Trust
- Diseases
- Pancreatic cancer
- NCT number
- NCT04902352
What you commit to
- Study type: Interventional
- Planned participants: 102
- From 6 Apr 2021 to the primary completion date, 6 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- All patients with benign disease or dysplasia with no evidence of malignancy
Age
- All paediatric patients (\< 18 years old)
Other
- Patients that cannot provide consent
- All borderline, locally advanced and metastatic pancreatic tumours on imaging (based on NCCN criteria)
- All patients with a cytological or histological diagnosis of cholangiocarcinoma, ampullary and duodenal carcinoma
Who the study is looking for
- All adult (≥ 18 years old) patients with a non-metastatic (based on NCCN definition) on imaging pancreatic tumour of the head or uncinate process treated with a pancreaticoduodenectomy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Birmingham NHS Foundation Trust Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.