NCT04904107Completed
Improving the Accuracy of Referrals of Patients With Chest Pain
A Multicentre Randomized Controlled Trial to Improve the accUracy of Referrals to the emerGency departmEnt of patieNts With chesT Pain by Using the Modified HEART Score in Emergency Medical Transport (URGENT 2.0)
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
This is a multicenter, prospective, investigator-initiated, randomized controlled trial aiming to reduce the percentage of non-cardiac chest pain (NCCP) patients admitted to the cardiac emergency department (ED) by performing the modified HEART score by emergency medical transport (EMT) personnel.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 852 (actual)
- First submitted
- 11 May 2021
- Start date
- 4 Jul 2021
- Primary completion date
- 3 Mar 2026
- Lead sponsor
- VieCuri Medical Centre
- Diseases
- Coronary artery disease
- NCT number
- NCT04904107
What you commit to
- Study type: Interventional
- Participants enrolled: 852
- From 4 Jul 2021 to the primary completion date, 3 Mar 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with confirmed ACS, PCI or CABG \<30 days prior to inclusion.
Other illness
- Suspicion of an acute non-coronary diagnosis e.g. pulmonary embolism, thoracic aortic dissection or other life-threatening disease.
- Patients presenting cardiogenic shock, defined as: systolic blood pressure \<90mmHg and heart rate \>100 and peripheral oxygen saturation \<90% (without oxygen administration)
- Patients presenting with sudden onset heart rhythm disorders and second or third degree atrioventricular block.
- Patients with known end-stage renal disease (dialysis and/or MDRD \< 30 ml/min).
- Patients with known cognitive impairment.
Other
- Electrocardiographic ST-segment elevation/High suspicion of STE-ACS.
- Impaired consciousness defined as an EMV \<8.
- Severe shortness of breath.
- Communication issues with patient/language barrier.
- Patients already participating in an interventional cardiology or cardiovascular trial.
Who the study is looking for
- Age ≥ 18 years.
- Chest pain or other complaints suspect of ACS for at least 2 hours where the GP or emergency medical personnel are in need of further diagnostics or risk stratification to come to a decision of referral.
- Patients, who have been informed of the nature of the study, agree to its provisions and have provided written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Laurentius Hospital Roermond Coordinator of this site? Confirm its status | Roermond | Netherlands | Unknown status |
| Viecuri Medical Centre Northern Limburg Coordinator of this site? Confirm its status | Venlo | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.