NCT04906668Active, not recruiting
ABLATE Versus PACE: PVI or AV Node Ablation and PM Implantation for Elderly Patients With Persistent AF
Pulmonary-vein Isolation or Ablation of Atrioventricular-node and Pacemaker Implantation for Elderly Patients With Persistent Atrial Fibrillation (ABLATE Versus PACE)
Source: ClinicalTrials.gov · Last updated 17 Sept 2025
Brief summary (registry, in English)
As patients age, symptom control and treatment of atrial fibrillation become equally difficult, often leading to increased hospitalization. ABLATE versus PACE is a prospective, randomized clinical trial comparing pacemaker implantation with AV node ablation with pulmonary vein isolation in terms of rehospitalization and quality of life in patients with persistent AF aged 75 years and older.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 196 (estimated)
- First submitted
- 19 May 2021
- Start date
- 1 May 2021
- Primary completion date
- 30 May 2026
- Lead sponsor
- St. Josefs-Hospital Wiesbaden GmbH
- Diseases
- Atrial fibrillation
- NCT number
- NCT04906668
What you commit to
- Study type: Interventional
- Planned participants: 196
- From 1 May 2021 to the primary completion date, 30 May 2026
- 12 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Surgical coronary revascularization (within the last 90 days) or current triple therapy after stent PCI
- concomitant participation in another registered trial
Other illness
- High-grade (III°) left cardiac valvular disease
Lab values
- impaired systolic left ventricular function (ejection fraction \< 50%)
Other
- pre-implanted pacemaker
- bradycardia-indication for pacemaker
- contraindication for PVI or pacemaker-implantation
- contraindication for oral anticoagulation
- body-mass-index BMI \> 40 kg/m2
- inability to give written informed consent
- life expectancy \< 12 months
- reversible cause of AF (e.g. thyrotoxicosis, alcohol ingestion)
Who the study is looking for
- Persistent AF according to current ESC guideline (2020)
- Symptoms EHRA classification II - IV despite guideline indicated medical therapy
- Age ≥ 75 years
- Capability of giving written informed consent
Age in the registry: 75 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitätsklinikum Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Unknown status |
| Kerckhoff Klinik, Bad Nauheim Coordinator of this site? Confirm its status | Bad Nauheim | Germany | Unknown status |
| Vivantes Klinikum am Urban Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Universitätsklinikum Essen Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| Universitätsklinikum Frankfurt am Main Coordinator of this site? Confirm its status | Frankfurt | Germany | Unknown status |
| Klinikum Fürth Coordinator of this site? Confirm its status | Fürth | Germany | Unknown status |
| Ev. Krankenhaus Hagen-Haspe Coordinator of this site? Confirm its status | Hagen | Germany | Unknown status |
| Asklepios Klinik St. Georg Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| Westpfalz-Klinikum - Kaiserslautern Coordinator of this site? Confirm its status | Kaiserslautern | Germany | Unknown status |
| Krankenhaus Landshut-Achdorf Coordinator of this site? Confirm its status | Landshut | Germany | Unknown status |
| Universitätsklinikum Münster Coordinator of this site? Confirm its status | Münster | Germany | Unknown status |
| St. Josefs-Hospital Wiesbaden GmbH Coordinator of this site? Confirm its status | Wiesbaden | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.