NCT04908449CompletedPhase 1
Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery
A Comparison of the Analgesic Effects of Pectointercostal Fascial Plane Block (PIFB) Alone Versus PIFB With Rectus Sheath Block (RSB) in Cardiac Surgery: a Prospective, Randomized Controlled Trial.
Source: ClinicalTrials.gov · Last updated 17 Nov 2025
Brief summary (registry, in English)
The purpose of this study is to determine if ultrasound-guided bilateral pectointercostal fascial plane blocks with bilateral rectus sheath blocks block decrease pain scores, decrease opioid consumption, improve respiratory function, and improve quality of recovery in patients recovering from elective cardiac surgery involving primary median sternotomy and mediastinal chest tubes in comparison to pectointercostal fascial plane blocks alone.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 62 (actual)
- First submitted
- 24 May 2021
- Start date
- 19 Jun 2023
- Primary completion date
- 8 Nov 2024
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Coronary artery disease
- NCT number
- NCT04908449
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 62
- From 19 Jun 2023 to the primary completion date, 8 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to peripheral nerve block (e.g. local infection, previous trauma to the block site)
- Suspected or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past two years
Other illness
- Allergy to bupivacaine or other amide local anesthetic
- Severe pulmonary or hepatic disease
- Neurological deficit or disorder
- Uncontrolled anxiety, schizophrenia, or other severe psychiatric disorder
Lab values
- Left ventricular ejection fraction (LVEF) \< 30%
Other
- Preoperative, intraoperative, or immediate post-operative placement of intra-aortic balloon pump or deployment of extra-corporeal membrane oxygenation (ECMO)
- Inability to understand or speak English
- Chronic opioid consumption (daily oral morphine equivalent of \>20 mg) in the past three months
Who the study is looking for
- Subjects scheduled for cardiac surgery involving primary median sternotomy and mediastinal chest tubes.
- Age 18-85 years of age
- BMI 18-50 kg/m2
- Weight \> 60 kg
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.