HANSE - Holistic Implementation Study Assessing a Northern German Interdisciplinary Lung Cancer Screening Effort

Other illness

• Comorbidity, which would unequivocally contraindicate either screening or treatment if lung cancer is detected.
• History of chest CT within the past year preceding the invitation.

Other

• Inability to undergo non-contrast CT (e.g. ≥ 200 kg body weight, inability to lie flat).
• Pregnancy
• Risk of non-compliance with study procedures.
  • Unable to give written consent
  • Patient's inability to fill in the questionnaire self-dependent
  • Limited knowledge of the German language
  • Inability to travel, residents of care facilities, etc.

• Male and female subjects aged 55-79 years
• Current or former smokers
• Subjects with calculated risk score PLCOM2012 ≥1.58% (6 yrs.) or NELSON inclusion criteria (current or former smokers \[those who had quit ≤10 years ago\] who had smoked \>15 cigarettes a day for \>25 years or \>10 cigarettes a day for \>30 years).
• Able and willing to give written informed consent In addition, non-qualifying subjects fulfilling inclusion criteria 1 (age), 2 (smoking history) and 4 (consent), but do not meet the inclusion criterion 3 (risk too low) will be asked to volunteer by contributing long-term outcome data informing of the development of lung cancer or death from lung cancer (about n=7100 randomly selected from all 3 centers, low-risk group). These subjects will be contacted via mail after a minimum of 5 year follow up to inquire if they developed lung cancer in the time between their recruitment and present. Non-responders will be followed by local registries and by phone. New lung cancer cases will be verified using official hospital or cancer registry documents.