NCT04918121Active, not recruitingEarly phase 1
A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery
Source: ClinicalTrials.gov · Last updated 10 Nov 2025
Brief summary (registry, in English)
This is a pilot study, which will include approximately five eyes of 5 patients. This study proposes that a sustained release steroid insert (Yutiq)1 be implanted along with a glaucoma drainage device (Ahmed Glaucoma Valve (AGV) Model FP7) when the patient is undergoing glaucoma tube implant surgery or combined glaucoma tube implant and cataract surgery. The primary aim of this study is to assess the safety and efficacy (controlling intraocular pressure) of the Yutiq inserts to reduce post-operative scarring in surgical glaucoma patients. It is expected that post-operative week 12 onwards there will be a clinically and statistically significant lower IOP in the study eyes than eyes in a group undergoing the same surgery without the Yutiq insert. The estimated duration of the present study is 3 years.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 5 (estimated)
- First submitted
- 2 Jun 2021
- Start date
- 20 Jul 2021
- Primary completion date
- Jun 2027
- Lead sponsor
- Sanjay Asrani
- Diseases
- Glaucoma
- NCT number
- NCT04918121
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 5
- From 20 Jul 2021 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of tube erosion in the same or the other eye
- Eyes receiving anti-VEGF therapy in the study eye
- Ocular surgery in the study eye within 3 months prior to enrollment.
- Treatment with an investigational drug or device within 30 days preceding the glaucoma surgery.
- Any eye needing urgent glaucoma surgery i.e. within 5 days of the baseline visit (to allow time for patients to review the study documents).
Other illness
- Allergy to corticosteroids or any component of Yutiq insert.
- Patients with active or suspected ocular or periocular infections including most viral diseases such as herpes simplex, vaccinia, varicella, mycobacterial infections and fungal diseases.
- History of systemic immunosuppressive therapy or the possible need thereof such as patients with rheumatoid arthritis, lupus or transplant (systemic or eye)
- History of steroid induced glaucoma
- Any severe acute or chronic medical or psychiatric condition that could increase the risk associated with study participation or could interfere with the interpretation of study results and, in the judgment of the investigator, could make the patient inappropriate for entry into this study.
Age
- Pregnant or lactating females or females of child bearing age who are not willing to use contraception for the duration of the study.
Other
- Media opacity precluding evaluation of retina and optic nerve in the study eye.
- Patients who have tested positive for human immune deficiency virus.
- Patients for whom any of the protocol procedures may pose a special risk not outweighed by the potential benefits of participating in the study.
- Patients who are unlikely to comply with the study protocol.
Who the study is looking for
- At least 18 years old at time of consent.
- Patient being consented for either glaucoma tube implant surgery in pseudophakic eyes or being consented for cataract surgery with glaucoma tube implant surgery.
- Diagnosis of any type of glaucoma except inflammation associated glaucomas such as with co-existing uveitis or neovascular glaucoma.
- Negative urine pregnancy test at baseline for women of childbearing potential.
- Subjects who are willing and able to comply with scheduled visits, treatment plan and other study procedures and are able to provide an informed consent document signed and dated by the subject
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke Eye Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.