NCT04920539CompletedPhase 1
In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 56 (actual)
- First submitted
- 17 May 2021
- Start date
- 8 Feb 2022
- Primary completion date
- 1 Dec 2025
- Lead sponsor
- Yale University
- Diseases
- HIV
- NCT number
- NCT04920539
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 56
- From 8 Feb 2022 to the primary completion date, 1 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Major medical conditions, e.g., myocardial infarction, hypertension, etc.
Other
- Positive pregnancy test and lactation;
- Weight greater than 166 kg (365 lbs)
Who the study is looking for
- HIV-positive
- Good medication adherence
- Negative urine toxicology for drugs of abuse (including cannabis)
- Good mental and physical health (other than HIV) as determined by history, psychiatric interview, collateral information, physical and laboratory examinations, ECG, and vital signs.
- HIV-negative
- Negative urine toxicology for drugs of abuse (including cannabis)
- Good mental and physical health as determined by history, psychiatric interview, collateral information, physical and laboratory examinations, ECG, and vital signs.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Connecticut Healthcare System Coordinator of this site? Confirm its status | West Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.