NCT04920799Completed
Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The overarching goal of this double-blind, randomized, crossover, placebo-controlled pilot trial was to inform the development of a fully powered trial to evaluate the effects of dietary nitrate supplementation in older adults with CAD. We aimed to address the following objectives: (a) assess the feasibility, tolerability, and safety of the study protocol; (b) gather preliminary evidence on the effects of nitrate-rich beetroot juice compared with nitrate-depleted beetroot juice (placebo), and estimate the effect sizes; and (c) determine if a full-scale definitive trial is justified.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 8 (actual)
- First submitted
- 27 May 2021
- Start date
- 12 Nov 2021
- Primary completion date
- 28 Aug 2025
- Lead sponsor
- University of Florida
- Diseases
- Coronary artery disease
- NCT number
- NCT04920799
What you commit to
- Study type: Interventional
- Participants enrolled: 8
- From 12 Nov 2021 to the primary completion date, 28 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months.
- Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone)
- Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation
Other illness
- Unstable angina, recent myocardial infarction or heart failure within 6 months
- Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant ongoing or recurrent illness
- Individuals who have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months
- Uncontrolled hypertension
Other
- Use of tobacco products including smoking traditional or e-cigarettes
- Unwilling to remain weight stable during study participation
Who the study is looking for
- Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization.
- Considered to have stable CAD on optimal medical therapy
- 60 to 85 years of age
- Males and females (females must be postmenopausal either natural or surgical)
- Able to give consent
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Integrative Cardiovascular Physiology Laboratory, University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.